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Discovery of a Potent, Selective, and Orally Active Human Epidermal Growth Factor Receptor-2 Sheddase Inhibitor for the Treatment of Breast Cancer

Yao, Wenqing ; Zhuo, Jincong ; Burns, David M. ; [et al.]

American Chemical Society (ACS) ; 2007

In: Journal of Medicinal Chemistry Vol. 50, No. 4 ( 2007-02-01), p. 603-606

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In: Journal of Medicinal Chemistry, American Chemical Society (ACS), Vol. 50, No. 4 ( 2007-02-01), p. 603-606

Type of Medium: Online Resource

ISSN: 0022-2623 , 1520-4804

URL: Article

DOI: 10.1021/jm061344o

DOI: 10.1021/jm061344o.s001

Language: English

Publisher: American Chemical Society (ACS)

Publication Date: 2007

detail.hit.zdb_id: 1491411-6

SSG: 15,3

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Corrigendum to “Compelling P1 substituent affect on metalloprotease binding profile enables the design of a novel cyclohexyl core scaffold with excellent MMP selectivity and HER-2 sheddase inhibition” [Bioorg. Med. Chem. Lett. 19 (2009) 3525]

Burns, David M. ; Li, Yun-Long ; Xu, Meizhong ; [et al.]

Elsevier BV ; 2009

In: Bioorganic & Medicinal Chemistry Letters Vol. 19, No. 19 ( 2009-10), p. 5814-

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In: Bioorganic & Medicinal Chemistry Letters, Elsevier BV, Vol. 19, No. 19 ( 2009-10), p. 5814-

Type of Medium: Online Resource

ISSN: 0960-894X

URL: Article

DOI: 10.1016/j.bmcl.2009.08.015

RVK:

VA 2620

Language: English

Publisher: Elsevier BV

Publication Date: 2009

detail.hit.zdb_id: 1501505-1

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Compelling P1 substituent affect on metalloprotease binding profile enables the design of a novel cyclohexyl core scaffold with excellent MMP selectivity and HER-2 sheddase inhibition

Burns, David M. ; Li, Yun-Long ; Shi, Eric ; [et al.]

Elsevier BV ; 2009

In: Bioorganic & Medicinal Chemistry Letters Vol. 19, No. 13 ( 2009-7), p. 3525-3530

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In: Bioorganic & Medicinal Chemistry Letters, Elsevier BV, Vol. 19, No. 13 ( 2009-7), p. 3525-3530

Type of Medium: Online Resource

ISSN: 0960-894X

URL: Article

DOI: 10.1016/j.bmcl.2009.04.143

RVK:

VA 2620

Language: English

Publisher: Elsevier BV

Publication Date: 2009

detail.hit.zdb_id: 1501505-1

SSG: 15,3

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Design and identification of selective HER-2 sheddase inhibitors via P1′ manipulation and unconventional P2′ perturbations to induce a molecular metamorphosis

Yao, Wenqing ; Zhuo, Jincong ; Burns, David M. ; [et al.]

Elsevier BV ; 2008

In: Bioorganic & Medicinal Chemistry Letters Vol. 18, No. 1 ( 2008-1), p. 159-163

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In: Bioorganic & Medicinal Chemistry Letters, Elsevier BV, Vol. 18, No. 1 ( 2008-1), p. 159-163

Type of Medium: Online Resource

ISSN: 0960-894X

URL: Article

DOI: 10.1016/j.bmcl.2007.10.108

RVK:

VA 2620

Language: English

Publisher: Elsevier BV

Publication Date: 2008

detail.hit.zdb_id: 1501505-1

SSG: 15,3

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