In:
BJPsych Open, Royal College of Psychiatrists, Vol. 3, No. 2 ( 2017-03), p. 85-90
Abstract:
There is growing interest in linking vitamin D deficiency with autism spectrum disorders (ASDs). The association between vitamin D deficiency during gestation, a critical period in neurodevelopment, and ASD is not well understood. Aims To determine the association between gestational vitamin D status and ASD. Method Based on a birth cohort ( n =4334), we examined the association between 25-hydroxyvitamin D (25OHD), assessed from both maternal mid-gestation sera and neonatal sera, and ASD (defined by clinical records; n =68 cases). Results Individuals in the 25OHD-deficient group at mid-gestation had more than twofold increased risk of ASD (odds ratio (OR)=2.42, 95% confidence interval (CI) 1.09 to 5.07, P =0.03) compared with the sufficient group. The findings persisted in analyses including children of European ethnicity only. Conclusions Mid-gestational vitamin D deficiency was associated with an increased risk of ASD. Because gestational vitamin D deficiency is readily preventable with safe, inexpensive and readily available supplementation, this risk factor warrants closer scrutiny.
Type of Medium:
Online Resource
ISSN:
2056-4724
DOI:
10.1192/bjpo.bp.116.004077
Language:
English
Publisher:
Royal College of Psychiatrists
Publication Date:
2017
detail.hit.zdb_id:
2829557-2
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