In:
Clinical & Experimental Allergy, Wiley, Vol. 49, No. 3 ( 2019-03), p. 331-340
Abstract:
Markers of microbial exposure are thought to be associated with risk of allergic sensitization; however, the associations are inconsistent and may be related to gene‐environment interactions. Objective To examine the relationship between polymorphisms in the CD 14 gene and allergic sensitization and whether sibling exposure, as a marker of microbial exposure, modified this relationship. Methods We used data from the Tasmanian Longitudinal Health Study and the Melbourne Atopy Cohort Study. Two CD 14 polymorphisms were genotyped. Allergic sensitization was defined by a positive response to a skin prick test. Sibling exposure was measured as cumulative exposure to siblings before age 6 months, 2 and 4 years. Logistic regression and multi‐level mixed‐effects logistic regression were used to examine the associations. Effect estimates across the cohorts were pooled using random‐effects meta‐analysis. Results CD 14 SNP s were not individually associated with allergic sensitization in either cohort. In TAHS , cumulative sibling exposure before age 6 months, 2 and 4 years was each associated with a reduced risk of allergic sensitization at age 45 years. A similar effect was observed in MACS . Meta‐analysis across the two cohorts showed consistent evidence of an interaction between cumulative sibling exposure before 6 months and the rs5744455‐ SNP ( P = 0.001) but not with the rs2569190‐ SNP ( P = 0.60). The pooled meta‐analysis showed that the odds of sensitization with increasing cumulative exposure to sibling before 6 months of age was 20.9% smaller in those with the rs5744455‐C‐allele than the T‐allele (OR = 0.83 vs 1.05, respectively). Conclusion and Clinical Relevance Cumulative sibling exposure reduced the risk of sensitization from childhood to middle age in genetically susceptible individuals.
Type of Medium:
Online Resource
ISSN:
0954-7894
,
1365-2222
DOI:
10.1111/cea.2019.49.issue-3
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
2186232-1
detail.hit.zdb_id:
2004469-0
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