In:
Journal of Medical Imaging and Radiation Oncology, Wiley, Vol. 62, No. 3 ( 2018-06), p. 313-319
Abstract:
Focal 18 F‐Fluoride uptake on blood‐pool phase PET represents regional hyperaemia, while it indicates osteoblastic activity on mineralization phase PET . This study investigates the link between regional hyperaemia and osteoblastic activity in inflammatory and chronic lesions of ankylosing spondylitis ( AS ) of the sacroiliac joints ( SIJ ) using dual‐phase 18 F‐Fluoride PET / MRI . Methods Thirteen patients (six men, seven women, age: 37 ± 10 years) with active AS prospectively underwent dual‐phase 18 F‐Fluoride PET / MRI . Blood‐pool phase PET was acquired 6 min and mineralization phase PET 40 min after injection of 158 ± 8 MB q 18 F‐Fluoride. SIJ quadrants ( SQ ) were assessed regarding inflammatory lesions represented by bone marrow oedema ( BME ), chronic AS lesions such as erosion, fat deposition ( FD ), sclerosis and ankylosis on MRI , and regarding focal 18 F‐Fluoride uptake on both PET datasets. Image quality ( IQ ) of both PET datasets and MRI was evaluated using a 4‐point Likert scale. Results Of 104 SQ , there were 63.4% SQ with FD , 42.3% SQ with BME , 26.9% SQ with erosions, 26% SQ with sclerosis and 10.6% SQ with ankylosis. BME alone was associated with focal 18 F‐Fluoride uptake in 63.6% SQ on blood‐pool phase and 90.9% SQ on mineralization phase 18 F‐Fluoride PET / MRI . Instead, FD , erosion, sclerosis, ankylosis were not associated with focal 18 F‐Fluoride uptake on either blood‐pool or mineralization phase 18 F‐Fluoride PET / MRI . SQ showing BME alone or a combination of BME and chronic AS lesions had a significantly higher percentage of focal 18 F‐Fluoride uptake on blood‐pool phase and mineralization phase PET / MRI than SQ showing AS lesions without BME ( P 〈 0.001). Both 18 F‐Fluoride PET datasets provided high IQ , albeit IQ of mineralization phase PET was superior to blood‐pool phase PET ( P 〈 0.001). Conclusion Dual‐phase 18 F‐Fluoride PET / MRI of the SIJ showed that inflammatory rather than chronic AS lesions are associated with regional hyperaemia and osteoblastic activity.
Type of Medium:
Online Resource
ISSN:
1754-9477
,
1754-9485
DOI:
10.1111/jmiro.2018.62.issue-3
DOI:
10.1111/1754-9485.12687
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2409071-2
Permalink