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  • Springer Science and Business Media LLC  (7)
  • Buchalla, Wolfgang  (7)
  • 1
    Online Resource
    Online Resource
    Ca2+ release and buffering effects of synthetic hydroxyapatite following bacterial acid challenge
    Springer Science and Business Media LLC ; 2020
    In:  BMC Oral Health Vol. 20, No. 1 ( 2020-12)
    Details
    In: BMC Oral Health, Springer Science and Business Media LLC, Vol. 20, No. 1 ( 2020-12)
    Abstract: Synthetic particulate hydroxyapatite (HAP; Ca 5 (PO 4 ) 3 (OH)) is used as ingredient in oral care products but its effects on cariogenic biofilms are not clear yet. The primary mode of action of HAP may be acting as a calcium phosphate reservoir when deposited in oral biofilms and release Ca 2+ and (hydrogen) phosphate ions upon bacterial acid challenge. The aim of this in vitro study was to test this hypothesis by investigating release of Ca 2+ ions and potential buffering effects from HAP upon bacterial acid challenge in planktonic cultures and biofilms of Streptococcus mutans . Methods Planktonic cultures of S. mutans were grown in BHI broth with 1% sucrose or with additional 5% HAP or 5% silica for up to 48 h. Separately, biofilms of S. mutans were grown in BHI for 72 h in total. After 24 h of this biofilm culture, either BHI alone or BHI with additional 0.5% HAP or 0.5% silica was added. After 48 h, BHI with 1% sucrose was added to allow bacterial acid formation. Ca 2+ release was determined colorimetrically and pH measurements were performed using a pH electrode. For statistical analysis, non-parametrical procedures were applied ( n  ≥ 10; Mann-Whitney U test; α = 0.05). Results Relevant release of Ca 2+ was only evident in planktonic cultures or biofilms with HAP but not in both other groups ( p  ≤ 0.001). In suspended biofilms with HAP, median pH was 4.77 after 72 h and about 0.5 pH units higher as compared to both other groups (4.28 or 4.32, respectively; p  ≤ 0.001). Conclusions Under the tested conditions, synthetic HAP releases Ca 2+ ions upon bacterial acid challenge and may also show some buffering capacity but further studies are needed to investigate whether the concentrations tested here can also be reached clinically in dental biofilms.
    Type of Medium: Online Resource
    ISSN: 1472-6831
    URL: Article
    DOI: 10.1186/s12903-020-01080-z
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2091511-1
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  • 2
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    Limited antimicrobial efficacy of oral care antiseptics in microcosm biofilms and phenotypic adaptation of bacteria upon repeated exposure
    Springer Science and Business Media LLC ; 2021
    In:  Clinical Oral Investigations Vol. 25, No. 5 ( 2021-05), p. 2939-2950
    Details
    In: Clinical Oral Investigations, Springer Science and Business Media LLC, Vol. 25, No. 5 ( 2021-05), p. 2939-2950
    Abstract: The aims of this study were to investigate the antimicrobial efficacy of antiseptics in saliva-derived microcosm biofilms, and to examine phenotypic adaption of bacteria upon repeated exposure to sub-inhibitory antiseptic concentrations. Methods Saliva-derived biofilms were formed mimicking caries- or gingivitis-associated conditions, respectively. Microbial compositions were analyzed by semiconductor-based 16S rRNA sequencing. Biofilms were treated with CHX, CPC, BAC, ALX, and DQC for 1 or 10 min, and colony forming units (CFU) were evaluated. Phenotypic adaptation of six selected bacterial reference strains toward CHX, CPC, and BAC was assessed by measuring minimum inhibitory concentrations (MICs) over 10 passages of sub-inhibitory exposure. Protein expression profiles were investigated by SDS-PAGE. Results Both biofilms showed outgrowth of streptococci and Veillonella spp., while gingivitis biofilms also showed increased relative abundances of Actinomyces , Granulicatella , and Gemella spp. Antiseptic treatment for 1 min led to no relevant CFU-reductions despite for CPC. When treated for 10 min, CPC was most effective followed by BAC, ALX, CHX, and DQC. Stable adaptations with up to fourfold MIC increases were found in E. coli toward all tested antiseptics, in E. faecalis toward CHX and BAC, and in S. aureus toward CPC. Adapted E. coli strains showed different protein expression as compared with the wildtype strain. Conclusion Antiseptics showed limited antimicrobial efficacy toward mature biofilms when applied for clinically relevant treatment periods. Bacteria showed phenotypic adaptation upon repeated sub-inhibitory exposure. Clinical relevance Clinicians should be aware that wide-spread use of antiseptics may pose the risk of inducing resistances in oral bacteria.
    Type of Medium: Online Resource
    ISSN: 1432-6981 , 1436-3771
    URL: Article
    DOI: 10.1007/s00784-020-03613-w
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 1472578-2
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  • 3
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    Longevity of posterior composite and compomer restorations in children placed under different types of anesthesia: a retrospective 5-year study
    Springer Science and Business Media LLC ; 2020
    In:  Clinical Oral Investigations Vol. 24, No. 1 ( 2020-1), p. 141-150
    Details
    In: Clinical Oral Investigations, Springer Science and Business Media LLC, Vol. 24, No. 1 ( 2020-1), p. 141-150
    Type of Medium: Online Resource
    ISSN: 1432-6981 , 1436-3771
    URL: Article
    DOI: 10.1007/s00784-019-02911-2
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 1472578-2
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  • 4
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    General diseases and medications in 687 patients reporting on adverse effects from dental materials
    Springer Science and Business Media LLC ; 2023
    In:  Clinical Oral Investigations Vol. 27, No. 8 ( 2023-05-22), p. 4447-4457
    Details
    In: Clinical Oral Investigations, Springer Science and Business Media LLC, Vol. 27, No. 8 ( 2023-05-22), p. 4447-4457
    Abstract: Examination of patients claiming adverse effects from dental materials can be very challenging. Particularly, systemic aspects must be considered besides dental and orofacial diseases and allergies. Therefore, the aim of this study was to investigate a cohort of 687 patients reporting on adverse effects from dental materials focusing on findings related to known general diseases or conditions or medication-related findings with relevance to their subjective complaints. Methods Six hundred eighty-seven patients visiting a specialized consultation on claimed adverse effects from dental materials were retrospectively investigated for their subjective complaints, findings related to known general diseases or conditions, medication-related findings, dental and orofacial findings, or allergies with relevance to their subjective complaints. Results The most frequent subjective complaints were burning mouth (44.1%), taste disorders (28.5%), and dry mouth (23.7%). In 58.4% of the patients, dental and orofacial findings relevant to their complaints could be found. Findings related to known general diseases or conditions or medication-related findings were found in 28.7% or 21.0% of the patients, respectively. Regarding medications, findings related to antihypertensives (10.0%) and psychotropic drugs (5.7%) were found most frequently. Relevant diagnosed allergies toward dental materials were found in 11.9%, hyposalivation in 9.6% of the patients. In 15.1% of the patients, no objectifiable causes for the expressed complaints could be found. Conclusions For patients complaining of adverse effects from dental materials, findings related to known general diseases or conditions and medications should be given particular consideration, while still in some patients, no objectifiable causes for their complaints can be found. Clinical relevance For patients complaining about adverse effects from dental materials, specialized consultations and close collaboration with experts from other medical fields are eligible.
    Type of Medium: Online Resource
    ISSN: 1436-3771
    URL: Article
    DOI: 10.1007/s00784-023-05064-5
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 1472578-2
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  • 5
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    One-year results of a novel self-adhesive bulk-fill restorative and a conventional bulk-fill composite in class II cavities—a randomized clinical split-mouth study
    Springer Science and Business Media LLC ; 2022
    In:  Clinical Oral Investigations Vol. 26, No. 1 ( 2022-01), p. 449-461
    Details
    In: Clinical Oral Investigations, Springer Science and Business Media LLC, Vol. 26, No. 1 ( 2022-01), p. 449-461
    Abstract: In the context of the phase-down of amalgam, development of easily applicable, permanent restorative materials is of high clinical interest. Aim of this study was to evaluate the clinical performance of a novel, tooth-colored, self-adhesive bulk-fill restorative (SABF, 3M Oral Care) and a conventional bulk-fill composite (Filtek One, 3M Oral Care; FOBF) for restoring class II cavities. The null-hypothesis tested was that both materials perform similar regarding clinical performance. Materials and methods In this randomized split-mouth study, 30 patients received one SABF and one FOBF restoration each. Scotchbond Universal (3M Oral Care) was used as adhesive for FOBF (self-etch mode), while SABF was applied directly without adhesive. Restorations were evaluated by two blinded examiners at baseline, 6 months and 12 months employing FDI criteria. Non-parametric statistical analyses and χ 2 -tests ( α  = 0.05) were applied. Results Thirty patients (60 restorations) were available for the 6- and 12-month recalls exhibiting 100% restoration survival. All restorations revealed clinically acceptable FDI scores at all time points and for all criteria. Only regarding esthetic properties, FOBF performed significantly better than SABF regarding surface lustre (A1) and color match and translucency (A3) at all time points and marginal staining (A2b) at 12 months. Conclusions The null-hypothesis could not be rejected. Both materials performed similarly regarding clinical performance within the first year of clinical service. SABF exhibited slightly inferior, but clinically fully acceptable esthetic properties as compared to FOBF. Clinical relevance Within the limitations of this study, the self-adhesive bulk-fill restorative showed promising results and may be recommended for clinical use.
    Type of Medium: Online Resource
    ISSN: 1432-6981 , 1436-3771
    URL: Article
    DOI: 10.1007/s00784-021-04019-y
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
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  • 6
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    Antimicrobial photodynamic therapy vs. local minocycline in addition to non-surgical therapy of deep periodontal pockets: a controlled randomized clinical trial
    Springer Science and Business Media LLC ; 2017
    In:  Clinical Oral Investigations Vol. 21, No. 7 ( 2017-9), p. 2253-2264
    Details
    In: Clinical Oral Investigations, Springer Science and Business Media LLC, Vol. 21, No. 7 ( 2017-9), p. 2253-2264
    Type of Medium: Online Resource
    ISSN: 1432-6981 , 1436-3771
    URL: Article
    DOI: 10.1007/s00784-016-2018-6
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2017
    detail.hit.zdb_id: 1472578-2
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  • 7
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    The impact of cationic substituents in phenalen-1-one photosensitizers on antimicrobial photodynamic efficacy
    Springer Science and Business Media LLC ; 2016
    In:  Photochemical & Photobiological Sciences Vol. 15, No. 1 ( 2016-01), p. 57-68
    Details
    In: Photochemical & Photobiological Sciences, Springer Science and Business Media LLC, Vol. 15, No. 1 ( 2016-01), p. 57-68
    Abstract: Light-mediated killing of pathogens by cationic photosensitizers (PS) is a promising antimicrobial approach avoiding resistance as being present upon the use of antibiotics. In this study we focused on the impact of the substituents in phenalen-1-one PS. Photodynamic efficacy depending on positively charged moieties including a primary aliphatic, quaternary aliphatic, aromatic ammonium and a guanidinium cation was investigated against Gram-positive and Gram-negative pathogens. Considering the altered steric demand and lipophilicity of these functional groups we deduced a structure–activity relationship. SAGUA was the most potent PS in this series reaching a maximum efficacy of ≥6log 10 steps of bacteria killing at a concentration of 10 μM upon irradiation with blue light (20 mW cm −2 ) for 60 s (1.2 J cm −2 ) without exhibiting inherent dark toxicity. Its guanidinium moiety may be able to form strong bidentate and directional hydrogen bonds to carboxylate groups of bacterial surfaces in addition to ionic charge attraction. This may supplement fast and effective antimicrobial activity.
    Type of Medium: Online Resource
    ISSN: 1474-905X , 1474-9092
    URL: Article
    DOI: 10.1039/c5pp00262a
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2016
    detail.hit.zdb_id: 2072584-X
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