In:
Journal of Surgical Oncology, Wiley, Vol. 118, No. 4 ( 2018-09), p. 657-663
Abstract:
This study aims to explore the effects of preoperative treatments on lymph nodes (LNs) counts after total gastrectomy with D2 lymphadenectomy in esophagogastric adenocarcinoma. Methods A retrospective analysis was performed for 446 patients with locally advanced esophagogastric adenocarcinoma. The patients were divided into three groups: surgery first (SF), preoperative chemotherapy (PCT), and preoperative chemoradiotherapy (PCRT). Clinical‐pathological data were analyzed. Results The case number in SF, PCT, and PCRT groups was 281, 109, and 56, respectively, and the median total LNs count was 32.0 (10.0‐102.0), 31.0 (12.0‐62.0), and 25.5 (10.0‐50.0), respectively, ( P 〈 0.001). Univariate and multivariate analyses demonstrated the total LNs count was lower in PCRT than SF/PCT ( P 〈 0.001), and had no correlation with tumor regression grades (TRGs). Subgroup comparison showed radiation target LNs count was lower in PCRT than SF/PCT ( P 〈 0.001), and peritarget LNs count was lower in PCRT than SF ( P = 0.002). Conclusion For esophagogastric adenocarcinoma, PCRT reduced total LNs count after total gastrectomy with D2 lymphadenectomy, whereas PCT did not. In the PCRT group, LNs count was lower in both radiation target and peritarget areas than in the SF group but only in radiation target area than in the PCT group. The correlation between TRGs and total LNs count remained unclear.
Type of Medium:
Online Resource
ISSN:
0022-4790
,
1096-9098
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
1475314-5
Permalink