In:
Journal of Cerebral Blood Flow & Metabolism, SAGE Publications, Vol. 23, No. 8 ( 2003-08), p. 972-977
Abstract:
The authors describe a new ultrasonographic method for analysis of global cerebral blood volume (CBV) and its application under controlled hyperventilation. CBV was determined as the product of global cerebral blood flow volume (CBF) and global cerebral circulation time. CBF was measured by duplex sonography and calculated as the sum of flow volumes in both internal carotid arteries and vertebral arteries. Extracranial Doppler assessed cerebral circulation time by determining the time interval of echo-contrast bolus arrival between internal carotid artery and contralateral internal jugular vein. Forty-four healthy volunteers (mean age 45 ± 19 years, range 20–79 years) were studied. Mean CBV was 77 ± 13 mL. CBV did not correlate with age, end-tidal carbon dioxide level, heart rate, or blood pressure. Hypocapnia was induced in 10 subjects by controlled hyperventilation. Mean reduction of end-tidal carbon dioxide values by 9 ± 1 mm Hg led to a significant increase in cerebral circulation time (6.1 ± 0.9 to 8.4 ± 1.1 second, P 〈 0.0001) and a significant CBF decrease (742 ± 85 to 526 ± 77 mL/min, P 〈 0.0001), whereas CBV remained unchanged (75 ± 6 to 73 ± 10 mL).
Type of Medium:
Online Resource
ISSN:
0271-678X
,
1559-7016
DOI:
10.1097/01.WCB.0000071884.63724.69
Language:
English
Publisher:
SAGE Publications
Publication Date:
2003
detail.hit.zdb_id:
2039456-1
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