In:
Clinical Physiology and Functional Imaging, Wiley, Vol. 29, No. 2 ( 2009-03), p. 100-107
Abstract:
Introduction: Self‐contained underwater breathing apparatus diving reduces cardiovascular function and increases pulmonary artery pressure (PAP) up to 3 days after a single dive. Acute antioxidants partially attenuated arterial endothelial dysfunction, whereas cardiac and PA functions were unaffected. We tested the hypothesis that acute tetrahydobiopterin (BH 4 ), as a cofactor of endothelial nitric oxide (NO) synthase, reduces bubble grade (BG) and attenuates alteration in cardiovascular function after diving because of increased NO bioavailability. Materials and methods: Mean PAP (mPAP), PA acceleration time and right ventricle ejection time, left ventricle ejection fraction (LV‐EF) and BG were measured after oral placebo (P), vitamin C (C) or a combination of vitamin C and BH 4 (BH 4 ) in a randomized, placebo controlled trial before and after field dive to 30 m of sea water for 30 min bottom time. Results: Eight recreational divers performed three dives with a 3‐days period between them. Regarding the primary hypothesis, no difference was observed between post‐dive changes in BG (2·1 ± 2·2 bubbles cm −2 for P, 3·4 ± 3·9 for C and 3·6 ± 2·1 for BH 4 ), mPAP (25·6 ± 6·5 mmHg for P, 25·9 ± 8·6 for C and 22·6 ± 3·5 for BH 4 ) and LV‐EF (62·6 ± 4·6% for P, 61·4 ± 3·9 for C and 61·6 ± 3·7 for BH 4 ) with all three conditions. Conclusion: This suggests that co‐administration of BH 4 and vitamin C does not improve heart and pulmonary artery function after diving.
Type of Medium:
Online Resource
ISSN:
1475-0961
,
1475-097X
DOI:
10.1111/cpf.2009.29.issue-2
DOI:
10.1111/j.1475-097X.2008.00845.x
Language:
English
Publisher:
Wiley
Publication Date:
2009
detail.hit.zdb_id:
2004626-1
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