In:
PLOS Pathogens, Public Library of Science (PLoS), Vol. 17, No. 12 ( 2021-12-23), p. e1009856-
Abstract:
Maternal anti-respiratory syncytial virus (RSV) antibodies acquired by the fetus through the placenta protect neonates from RSV disease through the first weeks of life. In the cotton rat model of RSV infections, we previously reported that immunization of dams during pregnancy with virus-like particles assembled with mutation stabilized pre-fusion F protein as well as the wild type G protein resulted in robust protection of their offspring from RSV challenge. Here we describe the durability of those protective responses in dams, the durability of protection in offspring, and the transfer of that protection to offspring of two consecutive pregnancies without a second boost immunization. We report that four weeks after birth, offspring of the first pregnancy were significantly protected from RSV replication in both lungs and nasal tissues after RSV challenge, but protection was reduced in pups at 6 weeks after birth. However, the overall protection of offspring of the second pregnancy was considerably reduced, even at four weeks of age. This drop in protection occurred even though the levels of total anti-pre-F IgG and neutralizing antibody titers in dams remained at similar, high levels before and after the second pregnancy. The results are consistent with an evolution of antibody properties in dams to populations less efficiently transferred to offspring or the less efficient transfer of antibodies in elderly dams.
Type of Medium:
Online Resource
ISSN:
1553-7374
DOI:
10.1371/journal.ppat.1009856
DOI:
10.1371/journal.ppat.1009856.g001
DOI:
10.1371/journal.ppat.1009856.g002
DOI:
10.1371/journal.ppat.1009856.g003
DOI:
10.1371/journal.ppat.1009856.g004
DOI:
10.1371/journal.ppat.1009856.g005
DOI:
10.1371/journal.ppat.1009856.g006
DOI:
10.1371/journal.ppat.1009856.g007
DOI:
10.1371/journal.ppat.1009856.g008
DOI:
10.1371/journal.ppat.1009856.s001
DOI:
10.1371/journal.ppat.1009856.s002
DOI:
10.1371/journal.ppat.1009856.s003
DOI:
10.1371/journal.ppat.1009856.s004
DOI:
10.1371/journal.ppat.1009856.s005
DOI:
10.1371/journal.ppat.1009856.s006
DOI:
10.1371/journal.ppat.1009856.s007
DOI:
10.1371/journal.ppat.1009856.s008
DOI:
10.1371/journal.ppat.1009856.s009
DOI:
10.1371/journal.ppat.1009856.s010
DOI:
10.1371/journal.ppat.1009856.s011
DOI:
10.1371/journal.ppat.1009856.s012
DOI:
10.1371/journal.ppat.1009856.s013
DOI:
10.1371/journal.ppat.1009856.s014
DOI:
10.1371/journal.ppat.1009856.s015
DOI:
10.1371/journal.ppat.1009856.s016
DOI:
10.1371/journal.ppat.1009856.s017
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2205412-1
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