In:
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, SAGE Publications, Vol. 51, No. 3 ( 2014-05), p. 412-415
Abstract:
A research on novel cardiovascular risk factors is mainly focused on patients with clinically verified coronary artery disease (CAD), while less is known about their presence in symptomatic patients, but without angiographically proven occlusion of coronary arteries. The aim of this study was to compare plasma low-density lipoprotein (LDL) and high-density lipoprotein (HDL) size and subclasses in stable angina patients with and without significant obstructive CAD. Methods LDL and HDL subclasses were analysed in 100 stable angina patients with ≥50% of obstruction and 40 patients with less than 50% of luminal narrowing, as assessed by coronary angiography. Results Patients with 〈 50% of obstruction had reduced mean HDL size and higher proportion of small HDL particles ( P 〈 0.05). HDL size and proportion of small HDL particles were significant and independent predictors of obstructive CAD ( P 〈 0.05, respectively). Conclusions Stable angina patients with 〈 50% of coronary obstruction have more favourable HDL subclasses distribution than patients with significant coronary stenosis.
Type of Medium:
Online Resource
ISSN:
0004-5632
,
1758-1001
DOI:
10.1177/0004563213499908
Language:
English
Publisher:
SAGE Publications
Publication Date:
2014
detail.hit.zdb_id:
2041298-8
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