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The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

Winkler, Thomas W. ; Justice, Anne E. ; Graff, Mariaelisa ; [weitere]

Public Library of Science (PLoS) ; 2015

In: PLOS Genetics Vol. 11, No. 10 ( 2015-10-1), p. e1005378-

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In: PLOS Genetics, Public Library of Science (PLoS), Vol. 11, No. 10 ( 2015-10-1), p. e1005378-

Materialart: Online-Ressource

ISSN: 1553-7404

URL: Article

DOI: 10.1371/journal.pgen.1005378

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Sprache: Englisch

Verlag: Public Library of Science (PLoS)

Publikationsdatum: 2015

ZDB Id: 2186725-2

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Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

Winkler, Thomas W. ; Justice, Anne E. ; Graff, Mariaelisa ; [weitere]

Public Library of Science (PLoS) ; 2016

In: PLOS Genetics Vol. 12, No. 6 ( 2016-6-29), p. e1006166-

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In: PLOS Genetics, Public Library of Science (PLoS), Vol. 12, No. 6 ( 2016-6-29), p. e1006166-

Materialart: Online-Ressource

ISSN: 1553-7404

URL: Article

DOI: 10.1371/journal.pgen.1006166

DOI: 10.1371/journal.pgen.1006166.s001

Sprache: Englisch

Verlag: Public Library of Science (PLoS)

Publikationsdatum: 2016

ZDB Id: 2186725-2

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Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

Pattaro, Cristian ; Teumer, Alexander ; Gorski, Mathias ; [weitere]

Springer Science and Business Media LLC ; 2016

In: Nature Communications Vol. 7, No. 1 ( 2016-01-21)

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In: Nature Communications, Springer Science and Business Media LLC, Vol. 7, No. 1 ( 2016-01-21)

Kurzfassung: Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular filtration rate (eGFR), combining data across 133,413 individuals with replication in up to 42,166 individuals. We identify 24 new and confirm 29 previously identified loci. Of these 53 loci, 19 associate with eGFR among individuals with diabetes. Using bioinformatics, we show that identified genes at eGFR loci are enriched for expression in kidney tissues and in pathways relevant for kidney development and transmembrane transporter activity, kidney structure, and regulation of glucose metabolism. Chromatin state mapping and DNase I hypersensitivity analyses across adult tissues demonstrate preferential mapping of associated variants to regulatory regions in kidney but not extra-renal tissues. These findings suggest that genetic determinants of eGFR are mediated largely through direct effects within the kidney and highlight important cell types and biological pathways.

Materialart: Online-Ressource

ISSN: 2041-1723

URL: Article

DOI: 10.1038/ncomms10023

Sprache: Englisch

Verlag: Springer Science and Business Media LLC

Publikationsdatum: 2016

ZDB Id: 2553671-0

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Genetic studies of body mass index yield new insights for obesity biology

Locke, Adam E. ; The LifeLines Cohort Study ; Kahali, Bratati ; [weitere]

Springer Science and Business Media LLC ; 2015

In: Nature Vol. 518, No. 7538 ( 2015-02-12), p. 197-206

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In: Nature, Springer Science and Business Media LLC, Vol. 518, No. 7538 ( 2015-02-12), p. 197-206

Materialart: Online-Ressource

ISSN: 0028-0836 , 1476-4687

URL: Article

DOI: 10.1038/nature14177

RVK:

TA 1000

RVK:

UA 1000

RVK:

WA 15000

Sprache: Englisch

Verlag: Springer Science and Business Media LLC

Publikationsdatum: 2015

ZDB Id: 120714-3

ZDB Id: 1413423-8

SSG: 11

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Rare and low-frequency coding variants alter human adult height

Marouli, Eirini ; Graff, Mariaelisa ; Medina-Gomez, Carolina ; [weitere]

Springer Science and Business Media LLC ; 2017

In: Nature Vol. 542, No. 7640 ( 2017-02-09), p. 186-190

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In: Nature, Springer Science and Business Media LLC, Vol. 542, No. 7640 ( 2017-02-09), p. 186-190

Materialart: Online-Ressource

ISSN: 0028-0836 , 1476-4687

URL: Article

DOI: 10.1038/nature21039

RVK:

TA 1000

RVK:

UA 1000

RVK:

WA 15000

Sprache: Englisch

Verlag: Springer Science and Business Media LLC

Publikationsdatum: 2017

ZDB Id: 120714-3

ZDB Id: 1413423-8

SSG: 11

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Directional dominance on stature and cognition in diverse human populations

Joshi, Peter K. ; The BioBank Japan Project ; Esko, Tonu ; [weitere]

Springer Science and Business Media LLC ; 2015

In: Nature Vol. 523, No. 7561 ( 2015-7), p. 459-462

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In: Nature, Springer Science and Business Media LLC, Vol. 523, No. 7561 ( 2015-7), p. 459-462

Materialart: Online-Ressource

ISSN: 0028-0836 , 1476-4687

URL: Article

DOI: 10.1038/nature14618

RVK:

TA 1000

RVK:

UA 1000

RVK:

WA 15000

Sprache: Englisch

Verlag: Springer Science and Business Media LLC

Publikationsdatum: 2015

ZDB Id: 120714-3

ZDB Id: 1413423-8

SSG: 11

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Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

Justice, Anne E. ; Winkler, Thomas W. ; Feitosa, Mary F. ; [weitere]

Springer Science and Business Media LLC ; 2017

In: Nature Communications Vol. 8, No. 1 ( 2017-04-26)

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In: Nature Communications, Springer Science and Business Media LLC, Vol. 8, No. 1 ( 2017-04-26)

Kurzfassung: Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent direction of effect for all identified loci and significance for 18 novel and for 5 interaction loci in an independent study sample. These loci highlight novel biological functions, including response to oxidative stress, addictive behaviour, and regulatory functions emphasizing the importance of accounting for environment in genetic analyses. Our results suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat distribution.

Materialart: Online-Ressource

ISSN: 2041-1723

URL: Article

DOI: 10.1038/ncomms14977

Sprache: Englisch

Verlag: Springer Science and Business Media LLC

Publikationsdatum: 2017

ZDB Id: 2553671-0

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Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Evangelou, Evangelos ; the Million Veteran Program ; Warren, Helen R. ; [weitere]

Springer Science and Business Media LLC ; 2018

In: Nature Genetics Vol. 50, No. 12 ( 2018-12), p. 1755-1755

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In: Nature Genetics, Springer Science and Business Media LLC, Vol. 50, No. 12 ( 2018-12), p. 1755-1755

Materialart: Online-Ressource

ISSN: 1061-4036 , 1546-1718

URL: Article

DOI: 10.1038/s41588-018-0297-3

RVK:

XA 10000

Sprache: Englisch

Verlag: Springer Science and Business Media LLC

Publikationsdatum: 2018

ZDB Id: 1494946-5

SSG: 12

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Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

Ng, Natasha ; Willems, Sara M. ; Fernandez, Juan ; [weitere]

Elsevier BV ; 2019

In: SSRN Electronic Journal

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In: SSRN Electronic Journal, Elsevier BV

Materialart: Online-Ressource

ISSN: 1556-5068

URL: Article

DOI: 10.2139/ssrn.3469835

Sprache: Englisch

Verlag: Elsevier BV

Publikationsdatum: 2019

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Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Evangelou, Evangelos ; the Million Veteran Program ; Warren, Helen R. ; [weitere]

Springer Science and Business Media LLC ; 2018

In: Nature Genetics Vol. 50, No. 10 ( 2018-10), p. 1412-1425

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In: Nature Genetics, Springer Science and Business Media LLC, Vol. 50, No. 10 ( 2018-10), p. 1412-1425

Materialart: Online-Ressource

ISSN: 1061-4036 , 1546-1718

URL: Article

DOI: 10.1038/s41588-018-0205-x

RVK:

XA 10000

Sprache: Englisch

Verlag: Springer Science and Business Media LLC

Publikationsdatum: 2018

ZDB Id: 1494946-5

SSG: 12

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