In:
PLOS Medicine, Public Library of Science (PLoS), Vol. 18, No. 7 ( 2021-7-9), p. e1003700-
Abstract:
Given the central role of skeletal muscles in glucose homeostasis, deposition of adipose depots beneath the fascia of muscles (versus subcutaneous adipose tissue [SAT]) may precede insulin resistance and type 2 diabetes (T2D) incidence. This study was aimed to investigate the associations between computed tomography (CT)–derived biomarkers for adipose tissue and T2D incidence in normoglycemic adults. Methods and findings This study was a population-based multiethnic retrospective cohort of 1,744 participants in the Multi-Ethnic Study of Atherosclerosis (MESA) with normoglycemia (baseline fasting plasma glucose [FPG] less than 100 mg/dL) from 6 United States of America communities. Participants were followed from April 2010 and January 2012 to December 2017, for a median of 7 years. The intermuscular adipose tissue (IMAT) and SAT areas were measured in baseline chest CT exams and were corrected by height squared (SAT and IMAT indices) using a predefined measurement protocol. T2D incidence, as the main outcome, was based on follow-up FPG, review of hospital records, or self-reported physician diagnoses. Participants’ mean age was 69 ± 9 years at baseline, and 977 (56.0%) were women. Over a median of 7 years, 103 (5.9%) participants were diagnosed with T2D, and 147 (8.4%) participants died. The IMAT index (hazard ratio [HR]: 1.27 [95% confidence interval [CI] : 1.15–1.41] per 1-standard deviation [SD] increment) and the SAT index (HR: 1.43 [95% CI: 1.16–1.77] per 1-SD increment) at baseline were associated with T2D incidence over the follow-up. The associations of the IMAT and SAT indices with T2D incidence were attenuated after adjustment for body mass index (BMI) and waist circumference, with HRs of 1.23 (95% CI: 1.09–1.38) and 1.29 (95% CI: 0.96–1.74) per 1-SD increment, respectively. The limitations of this study include unmeasured residual confounders and one-time measurement of adipose tissue biomarkers. Conclusions In this study, we observed an association between IMAT at baseline and T2D incidence over the follow-up. This study suggests the potential role of intermuscular adipose depots in the pathophysiology of T2D. Trial registration ClinicalTrials.gov NCT00005487
Type of Medium:
Online Resource
ISSN:
1549-1676
DOI:
10.1371/journal.pmed.1003700
DOI:
10.1371/journal.pmed.1003700.g001
DOI:
10.1371/journal.pmed.1003700.g002
DOI:
10.1371/journal.pmed.1003700.t001
DOI:
10.1371/journal.pmed.1003700.t002
DOI:
10.1371/journal.pmed.1003700.s001
DOI:
10.1371/journal.pmed.1003700.s002
DOI:
10.1371/journal.pmed.1003700.s003
DOI:
10.1371/journal.pmed.1003700.s004
DOI:
10.1371/journal.pmed.1003700.s005
DOI:
10.1371/journal.pmed.1003700.s006
DOI:
10.1371/journal.pmed.1003700.s007
DOI:
10.1371/journal.pmed.1003700.s008
DOI:
10.1371/journal.pmed.1003700.s009
DOI:
10.1371/journal.pmed.1003700.s010
DOI:
10.1371/journal.pmed.1003700.s011
DOI:
10.1371/journal.pmed.1003700.s012
DOI:
10.1371/journal.pmed.1003700.s013
DOI:
10.1371/journal.pmed.1003700.s014
DOI:
10.1371/journal.pmed.1003700.s015
DOI:
10.1371/journal.pmed.1003700.s016
DOI:
10.1371/journal.pmed.1003700.s017
DOI:
10.1371/journal.pmed.1003700.s018
DOI:
10.1371/journal.pmed.1003700.r001
DOI:
10.1371/journal.pmed.1003700.r002
DOI:
10.1371/journal.pmed.1003700.r003
DOI:
10.1371/journal.pmed.1003700.r004
DOI:
10.1371/journal.pmed.1003700.r005
DOI:
10.1371/journal.pmed.1003700.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2164823-2
Permalink