In:
Pest Management Science, Wiley, Vol. 61, No. 6 ( 2005-06), p. 605-611
Abstract:
An analytical method to evaluate propionylpromazine hydrochloride (PPZHCl) in tranquilizer formulations was developed using high‐performance liquid chromatography (HPLC). During analysis of aged quality‐control samples, a previously unreported chromatographic response was observed at a shorter retention time than PPZHCl. Further investigation of formulations stored in trap tap devices at temperatures ranging from 5 to 40 °C during field trials at four different locations confirmed the degradation of the active ingredient. Further investigation using HPLC/tandem mass spectrometry revealed two to five degradates, with the major degradates being oxidation products of the active ingredient, PPZHCl. As PPZHCl formulations must be stable when stored at 5 to 40 °C for 6 to 12 months, reformulation with the anti‐oxidant ascorbic acid was utilized to achieve the required PPZHCl stability. Copyright © 2005 Society of Chemical Industry
Type of Medium:
Online Resource
ISSN:
1526-498X
,
1526-4998
Language:
English
Publisher:
Wiley
Publication Date:
2005
detail.hit.zdb_id:
2003455-6
SSG:
12
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