In:
Chemistry & Biodiversity, Wiley, Vol. 16, No. 4 ( 2019-04)
Abstract:
Di(indol‐3‐yl)methane (=3,3′‐methanediyldi(1 H ‐indole), DIM, 1 ) is a known weakly antitumoral compound formed by digestion of indole‐3‐carbinol (=1 H ‐indol‐3‐ylmethanol), an ingredient of various Brassica vegetables. Out of a series of nine fluoroaryl derivatives of 1 , three pentafluorophenyl derivatives 2c , 2h , and 2i were identified that exhibited a two to five times greater anti‐proliferative effect and an increased apoptosis induction when compared with 1 in the following carcinoma cell lines: BxPC‐3 pancreas, LNCaP prostate, C4‐2B prostate, PC3 prostate and the triple‐negative MDA‐MB‐231 breast carcinoma. Compound 2h was particularly efficacious against androgen‐refractory C4‐2B prostate cancer cells (IC 50 =6.4 μ m ) and 2i against androgen‐responsive LNCaP cells (IC 50 =6.2 μ m ). In addition, 2c and 2h exhibited distinct activity in three cancer cell lines resistant to 1 .
Type of Medium:
Online Resource
ISSN:
1612-1872
,
1612-1880
DOI:
10.1002/cbdv.201900028
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
2139001-0
SSG:
12
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