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  • Bierman, C. Warren  (3)
  • 1980-1984  (3)
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  • 1980-1984  (3)
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  • 1
    Online Resource
    Online Resource
    Letter to the Editor
    American Academy of Pediatrics (AAP) ; 1982
    In:  Pediatrics Vol. 70, No. 3 ( 1982-09-01), p. 509-509
    Details
    In: Pediatrics, American Academy of Pediatrics (AAP), Vol. 70, No. 3 ( 1982-09-01), p. 509-509
    Abstract: We thank Walker and Middelkamp for sharing their experiences. We also would like to emphasize Weinberger's point that when nausea, vomiting, or headache are present in nonwheezing children, additional theophylline administration should always be withheld until a serum theophylline level is measured. Theophylline continues to be very effective in the treatment of chronic asthma, and its use is to be encouraged. However, for optimal benefits with minimal risks, serum theophylline determinations must be rapidly obtainable.
    Type of Medium: Online Resource
    ISSN: 0031-4005 , 1098-4275
    URL: Article
    DOI: 10.1542/peds.70.3.509
    Language: English
    Publisher: American Academy of Pediatrics (AAP)
    Publication Date: 1982
    detail.hit.zdb_id: 1477004-0
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    Online Resource
  • 2
    Online Resource
    Online Resource
    A Double-Blind Study Comparing the Effectiveness of Cromolyn Sodium and Sustained-Release Theophylline in Childhood Asthma
    American Academy of Pediatrics (AAP) ; 1984
    In:  Pediatrics Vol. 74, No. 4 ( 1984-10-01), p. 453-459
    Details
    In: Pediatrics, American Academy of Pediatrics (AAP), Vol. 74, No. 4 ( 1984-10-01), p. 453-459
    Abstract: The effectiveness of cromolyn sodium and theophylline on asthma in children was compared during a 3-month trial. Forty-six children (aged 5 to 15 years) with asthma were assigned at random to cromolyn or theophylline (Theo-Dur) treatment groups. Each subject received theophylline placebo or cromolyn placebo in addition to the active drugs. A methacholine challenge test was done at the start of the study to document asthma and was repeated during the third month. The theophylline dosage was regulated to obtain serum levels of 10 to 15 µg/mL by a physician not involved directly with patient care. Forty patients completed the study. Both theophylline and cromolyn treatment groups showed improvement from base-line status in terms of symptom scores, pulmonary function, and decreased use of inhaled albuterol. Patients treated with theophylline had more side effects and required more frequent office visits than those treated with cromolyn. Both groups had decreased sensitivity to methacholine, and for one statistical test patients treated with cromolyn improved significantly. These results indicate that cromolyn is as effective as theophylline in treating mild to moderate asthma in children; additional benefits were fewer side effects and a possible decrease in bronchial hyperactivity.
    Type of Medium: Online Resource
    ISSN: 0031-4005 , 1098-4275
    URL: Article
    DOI: 10.1542/peds.74.4.453
    Language: English
    Publisher: American Academy of Pediatrics (AAP)
    Publication Date: 1984
    detail.hit.zdb_id: 1477004-0
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    Online Resource
  • 3
    Online Resource
    Online Resource
    Altered Theophylline Clearance During an Influenza B Outbreak
    American Academy of Pediatrics (AAP) ; 1982
    In:  Pediatrics Vol. 69, No. 4 ( 1982-04-01), p. 476-480
    Details
    In: Pediatrics, American Academy of Pediatrics (AAP), Vol. 69, No. 4 ( 1982-04-01), p. 476-480
    Abstract: During the 1980 influenza B outbreak in King County, Washington, 11 children whose asthma had previously been controlled with a stable theophylline dose, developed theophylline toxicity on this same dose. Two had seizures, eight had nausea and vomiting, and three had headaches. All had clinical evidence of a febrile viral illness. The toxicity appeared to be related to decreased theophylline clearance, which gradually returned to preillness levels over a period of one to three months. Six of ten children had serologic evidence of influenza B, which is presumed to be the cause of the altered clearance. In children receiving chronic theophylline therapy, symptoms of vomiting, headaches, or seizures during a viral illness may be due to theophylline toxicity rather than the virus. Such patients should have an immediate serum theophylline determination, even if previous levels have been in the therapeutic range.
    Type of Medium: Online Resource
    ISSN: 0031-4005 , 1098-4275
    URL: Article
    DOI: 10.1542/peds.69.4.476
    Language: English
    Publisher: American Academy of Pediatrics (AAP)
    Publication Date: 1982
    detail.hit.zdb_id: 1477004-0
    Location Call Number Limitation Availability
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    Online Resource
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