In:
Future Oncology, Future Medicine Ltd, Vol. 12, No. 5 ( 2016-03), p. 625-635
Abstract:
Aim: This study analyzes our single-center, retrospective experience on 63 premenopausal breast cancer patients treated with monthly triptorelin and concomitant chemotherapy. Patients & methods: Concomitant chemotherapy and triptorelin were adopted as part of premature ovarian failure prevention strategy. Results: Age at diagnosis was the main factor influencing fertility preservation (p = 0.002). Compared with patients aged 41–45 years, the probability of menses resumption was almost threefold than for women aged 35–40 years, and significantly higher for women aged 〈 35 years (hazard ratio: 9.0; p = 0.0001). The cumulative proportion among patients who resumed menses was 33.3% at 6 months, 75% at 12 months and 87.5% at 24 months. Seven patients attempted pregnancy, and five (71%) obtained healthy deliveries. Conclusion: We observed an acceptable rate of fertility preservation. Age at diagnosis influences fertility preservation.
Type of Medium:
Online Resource
ISSN:
1479-6694
,
1744-8301
Language:
English
Publisher:
Future Medicine Ltd
Publication Date:
2016
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