In:
Movement Disorders Clinical Practice, Wiley
Abstract:
Foslevodopa/foscarbidopa is a subcutaneous infusion of levodopa/carbidopa prodrugs. Objectives Assess correlations between sleep and efficacy from interim data of a phase 3 trial of foslevodopa/foscarbidopa (NCT03781167). Methods Pearson correlations between sleep (Parkinson's Disease Sleep Scale‐2 [PDSS‐2]) and quality of life (QoL; Parkinson's Disease Questionnaire‐39), motor experiences of daily living (m‐EDL; Movement Disorder Society‐Unified Parkinson's Disease Scale Part II), and “Off”/“On” times were calculated for baseline and week 26 improvements. Regression analyses were adjusted for baseline PDSS‐2 score. Results Baseline sleep correlated moderately with QoL ( r = 0.44, P 〈 0.001) and weakly with m‐EDL ( r = 0.28; P 〈 0.001). Sleep improvement weakly correlated with improved “Off” time ( r = 0.37; P 〈 0.001) and QoL ( r = 0.36; P 〈 0.001). Regression analyses demonstrated significant positive associations for improved sleep, “Off” time, QoL, and m‐EDL. Conclusions Improved sleep with foslevodopa/foscarbidopa was associated with improved QoL and “Off” time.
Type of Medium:
Online Resource
ISSN:
2330-1619
,
2330-1619
Language:
English
Publisher:
Wiley
Publication Date:
2024
detail.hit.zdb_id:
2772809-2
Permalink