In:
Chemistry – A European Journal, Wiley, Vol. 26, No. 10 ( 2020-02-17), p. 2211-2221
Abstract:
The synthesis, characterization and biological activity of molybdenum(IV) complexes containing Trofimenko's scorpionato ligand, hydrotris(3‐isopropylpyrazolyl)borate (Tp i Pr ), in addition to varying biologically active as well as other conventional ligands is described. Ligands employed include ( O,O ‐) ( S,O ‐) ( N , N ‐) donors that have been successfully coordinated to the molybdenum center by means of oxygen‐atom transfer (OAT) reactions from the known Mo VI starting material, Tp i Pr MoO 2 Cl. The synthesized complexes were characterized by standard analytical methods and where possible by X‐ray diffraction analysis. The aqueous stability of the compounds was studied by means of UV/Vis spectroscopy and the impact of the attached ligand scaffolds on the oxidation potentials (Mo IV to Mo V ) was studied by cyclic voltammetry. Utilizing polyvinylpyrrolidone (PVP) as a solubilizing agent, adequate aqueous solubility for biological tests was obtained. Anticancer activity tests and preliminary mode of action studies have been performed in vitro and in vivo.
Type of Medium:
Online Resource
ISSN:
0947-6539
,
1521-3765
DOI:
10.1002/chem.201903605
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
1478547-X
detail.hit.zdb_id:
1231884-X
Permalink