In:
Thorax, BMJ, Vol. 73, No. 6 ( 2018-06), p. 578-580
Abstract:
Respiratory syncytial virus (RSV) infection is characterised by airway obstruction with mucus plugs, containing DNA networks in the form of neutrophil extracellular traps (NETs). We investigated the effect of dornase alfa on histopathological NETs-induced airway obstruction and viral load in an age-relevant calf model of severe bovine RSV disease. As compared with the control animals, dornase alfa treatment resulted in a strong reduction of NETs-induced airway obstruction. Viral load in the lower respiratory tract was not different between the two groups. We conclude that NETs form a relevant target for treatment of airway obstruction in severe RSV disease.
Type of Medium:
Online Resource
ISSN:
0040-6376
,
1468-3296
DOI:
10.1136/thoraxjnl-2017-210289
DOI:
10.1136/thoraxjnl-2017-210289.supp1
DOI:
10.1136/thoraxjnl-2017-210289.supp2
DOI:
10.1136/thoraxjnl-2017-210289.supp3
Language:
English
Publisher:
BMJ
Publication Date:
2018
detail.hit.zdb_id:
1481491-2
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