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  • 1
    Online Resource
    Online Resource
    Inflammatory Biomarkers in Exhaled Breath Condensate: A Systematic Review
    MDPI AG ; 2022
    In:  International Journal of Molecular Sciences Vol. 23, No. 17 ( 2022-08-29), p. 9820-
    Details
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 23, No. 17 ( 2022-08-29), p. 9820-
    Abstract: Inflammation is a comprehensive set of physiological processes that an organism undertakes in response to a wide variety of foreign stimuli, such as viruses, bacteria, and inorganic particles. A key role is played by cytokines, protein-based chemical mediators produced by a broad range of cells, including the immune cells recruited in the inflammation site. The aim of this systematic review is to compare baseline values of pro/anti-inflammatory biomarkers measured in Exhaled Breath Condensate (EBC) in healthy, non-smoking adults to provide a summary of the concentrations reported in the literature. We focused on: interleukin (IL)-1β, IL-4, IL-6, IL-8, IL-10, tumour necrosis factor-alpha (TNF-α), and C reactive protein (CRP). Eligible articles were identified in PubMed, Embase, and Cochrane CENTRAL. Due to the wide differences in methodologies employed in the included articles concerning EBC sampling, storage, and analyses, research protocols were assessed specifically to test their adherence to the ATS/ERS Task Force guidelines on EBC. The development of reference intervals for these biomarkers can result in their introduction and use in both research and clinical settings, not only for monitoring purposes but also, in the perspective of future longitudinal studies, as predictive parameters for the onset and development of chronic diseases with inflammatory aetiology.
    Type of Medium: Online Resource
    ISSN: 1422-0067
    URL: Article
    DOI: 10.3390/ijms23179820
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2019364-6
    SSG: 12
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  • 2
    Online Resource
    Online Resource
    145 Cumulative Occupational Exposure to Nanoparticles, Inflammatory Biomarkers and Respiratory Health in the Nanoexplore Cohort
    Oxford University Press (OUP) ; 2023
    In:  Annals of Work Exposures and Health Vol. 67, No. Supplement_1 ( 2023-05-10), p. i100-i100
    Details
    In: Annals of Work Exposures and Health, Oxford University Press (OUP), Vol. 67, No. Supplement_1 ( 2023-05-10), p. i100-i100
    Abstract: Exposure to nanomaterials (NMs) may harm biological systems by altering the redox status and triggering inflammatory processes, which in turn may affect respiratory health. In the NanoExplore cohort of 141 workers, we observed a positive dose-response relationship between the short-term exposure to NMs and biomarkers of inflammation, measured in Exhaled Breath Condensate (EBC), but no relationship with lung function parameters (LFP). This study focuses on the association between cumulative exposure to NMs over the last 10 years and changes in LFP and the potential mediating role of airways inflammation. Individual cumulative exposure was estimated by multiplying the nanoparticle concentration, measured at workers’ workstations by DiSCmini, by the duration of worker’s employment at the corresponding workstation up to last 10 years. In EBC, we measured High-Sensitivity CRP (Hs-CRP), IL-1β, TNF-α, and IL-10 as biomarkers of inflammation. LFP were assessed according to ATS/ERS standards. Their association with cumulative exposure was examined using logistic regression models adjusted for tobacco consumption (in pack-years), among 136 workers with complete data (19-62 yrs., 70% males). We found that per unit increase in 10-year exposure, the risk of observing FEV1 values below the normal limit increases by 0.3% (95%CI: 1.000-1.005, p=0.049) and by 0.8% (95%CI: 1.000-1.015, p=0.039) with the exposure expressed as number of particles and lung deposited surface area, respectively. The ongoing mediation analysis will investigate the potential mediating role of inflammation in the association between cumulative exposure to NMs and lung function
    Type of Medium: Online Resource
    ISSN: 2398-7308 , 2398-7316
    URL: Article
    DOI: 10.1093/annweh/wxac087.245
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
    detail.hit.zdb_id: 2003484-2
    detail.hit.zdb_id: 2885099-3
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  • 3
    Online Resource
    Online Resource
    144 Occupational Exposure to Particles Measured by Nanoparticles Tracking Analysis (NTA) in Exhaled Breath Condensate (EBC).
    Oxford University Press (OUP) ; 2023
    In:  Annals of Work Exposures and Health Vol. 67, No. Supplement_1 ( 2023-05-10), p. i99-i100
    Details
    In: Annals of Work Exposures and Health, Oxford University Press (OUP), Vol. 67, No. Supplement_1 ( 2023-05-10), p. i99-i100
    Abstract: The production of paints, coatings and construction materials may generate nanoparticles (NP) with potential adverse health effects. We carried out a study aimed at investigating exposure biomarkers reflecting the internal dose of inhaled particles and NP. NTA was used to quantify particle number concentration and size in EBC collected at the end of shift in 81 workers employed in companies producing technological materials. External exposure was characterized in terms of particle number concentration, size and lung deposited surface area (LDSA) in the near operational field by using a set of DiSCmini. Three subgroups were identified: Low-Exposure (LE, n=30), High-Exposure (HE n=35), and non-occupationally exposed (UC, n=16). Comparisons between groups were made using non-parametric analyses. LE and HE workers showed significantly higher number of NP in EBC (p=0.024, p=0.041, respectively) as compared to UC. The HE groups showed higher levels of inflammatory biomarkers, such as IL-1β and IL-10 as compared to LE and UC (p=0.02, p & lt;0.01, respectively). Positive correlations were observed between particle number concentration recorded by DiscMini and NTA data (Rho=0,225, p=0.04) and between the NTA and IL-10 and IL-1β (Rho=0.246, p=0.012; Rho=0.223, p=0.022, respectively). In contrast, LDSA did not correlate with NTA data. These findings provide evidence of the relationship between increasing exposure to NP and the burden of particles in the airways which, in turn, results in sustained inflammation. Given the lack of exposure biomarkers for dusts, these results are promising to investigate the relationship between internal dose of particles and changes in lung pathobiology.
    Type of Medium: Online Resource
    ISSN: 2398-7308 , 2398-7316
    URL: Article
    DOI: 10.1093/annweh/wxac087.244
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
    detail.hit.zdb_id: 2003484-2
    detail.hit.zdb_id: 2885099-3
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  • 4
    Online Resource
    Online Resource
    143 Urinary Metals Exposure and Oxidative Stress Biomarkers in Nanotechnology Workers: Results from the Nanoexplore Project
    Oxford University Press (OUP) ; 2023
    In:  Annals of Work Exposures and Health Vol. 67, No. Supplement_1 ( 2023-05-10), p. i72-i73
    Details
    In: Annals of Work Exposures and Health, Oxford University Press (OUP), Vol. 67, No. Supplement_1 ( 2023-05-10), p. i72-i73
    Abstract: Exposure to metal oxides nanomaterials (NMs) might trigger adverse health effects. NMs can generate Oxidative Stress (OS), causing redox effects detectable in urine through suitable biomarkers. We evaluated the cross-sectional association of urinary OS biomarkers with urinary metal concentrations, using data collected in the multicenter international study NanoExplore. One hundred forty-one workers were recruited at three R & D and four industrial facilities employing NMs in different processes (paints/coating[PC];construction chemicals[CC] ). Only 129 workers had complete data and, based on the personal work-shift exposure to NMs, they were classified as unexposed workers (n=41), workers with negligible/low exposure (n=37), and with moderate/high exposure (n=51). OS biomarkers (IsoP,MDA,TAP) and metals (27Al,47Ti,52Cr,118Sn) were quantified in urine samples collected before and after exposure monitoring campaign (2-4 work-shifts).  Between-group comparisons were performed with non-parametric tests according to the data distribution. Highly exposed workers had significantly higher pro-oxidant (IsoP and MDA,p & lt;0.005) and antioxidant (TAP,p & lt;0.05) biomarkers concentrations. 47Ti,118Sn and 29Si were significantly higher in CC workers (p & lt;0.005). IsoP and TAP were positively associated with 29Si (both p & lt;0.001), 47Ti (p=0.036,p=0.003), 52Cr (p=0.048,p=0.003) and 118Sn (p=0.047,p=0.022). The ongoing analyses will assess the potential mediation role of OS and metal biomarkers. Occupational exposure to NMs can represent an underestimated hazard for people handling NMs products, increasing OS and potentially beginning pathological processes. Although the health significance of such findings needs to be further elucidated, the assessment of metals in urine may represent a useful tool for estimating the body burden of NMs long-term exposure.
    Type of Medium: Online Resource
    ISSN: 2398-7308 , 2398-7316
    URL: Article
    DOI: 10.1093/annweh/wxac087.175
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
    detail.hit.zdb_id: 2003484-2
    detail.hit.zdb_id: 2885099-3
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  • 5
    Online Resource
    Online Resource
    Exposure to engineered nanomaterials and early biological effects measured in the exhaled breath condensate: First results from the NanoExplore cohort
    Environmental Health Perspectives ; 2022
    In:  ISEE Conference Abstracts Vol. 2022, No. 1 ( 2022-09-18)
    Details
    In: ISEE Conference Abstracts, Environmental Health Perspectives, Vol. 2022, No. 1 ( 2022-09-18)
    Type of Medium: Online Resource
    ISSN: 1078-0475
    URL: Article
    DOI: 10.1289/isee.2022.P-1158
    Language: English
    Publisher: Environmental Health Perspectives
    Publication Date: 2022
    detail.hit.zdb_id: 2028870-0
    SSG: 27
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