In:
International Journal of Cancer, Wiley, Vol. 139, No. 2 ( 2016-07-15), p. 467-479
Abstract:
What's new? Trabectedin kills tumor cells by binding to DNA and inducing double‐strand breaks. An impaired DNA repair mechanism makes a tumor more susceptible to trabectedin treatment, and heat inactivates certain proteins involved in DNA double‐strand break repair. The authors found that heat improves trabectedin‐induced cell death in sarcoma cell lines. This enhancement results from the degradation of BRCA2, they conclude: on‐demand inhibition of DNA repair by heat is a promising strategy to improve effectiveness of trabectedin.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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