In:
Journal of Cell Biology, Rockefeller University Press, Vol. 203, No. 5 ( 2013-12-09), p. 757-766
Abstract:
Antigen preservation for presentation is a hallmark of potent antigen-presenting cells. In this paper, we report that in human macrophages and dendritic cells, a subset of phagosomes gets coated with Atg8/LC3, a component of the molecular machinery of macroautophagy, and maintains phagocytosed antigens for prolonged presentation on major histocompatibility complex class II molecules. These Atg8/LC3-positive phagosomes are formed around the antigen with TLR2 agonists and require reactive oxygen species production by NOX2 for their generation. A deficiency in the NOX2-dependent formation of these antigen storage phagosomes could contribute to compromise antifungal immune control in chronic granulomatous disease patients.
Type of Medium:
Online Resource
ISSN:
1540-8140
,
0021-9525
DOI:
10.1083/jcb.201308173
DOI:
10.1083/jcb.201308173.dv
Language:
English
Publisher:
Rockefeller University Press
Publication Date:
2013
detail.hit.zdb_id:
1421310-2
SSG:
12
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