In:
Annals of Surgical Oncology, Springer Science and Business Media LLC, Vol. 30, No. 1 ( 2023-01), p. 35-45
Abstract:
This study seeks to evaluate the impact of breast cancer ( BRCA ) gene status on tumor dissemination pattern, surgical outcome and survival in a multicenter cohort of paired primary ovarian cancer (pOC) and recurrent ovarian cancer (rOC). Patients and Methods Medical records and follow-up data from 190 patients were gathered retrospectively. All patients had surgery at pOC and at least one further rOC surgery at four European high-volume centers. Patients were divided into one cohort with confirmed mutation for BRCA1 and/or BRCA2 ( BRCA mut) and a second cohort with BRCA wild type or unknown ( BRCA wt). Patterns of tumor presentation, surgical outcome and survival data were analyzed between the two groups. Results Patients with BRCA mut disease were on average 4 years younger and had significantly more tumor involvement upon diagnosis. Patients with BRCA mut disease showed higher debulking rates at all stages. Multivariate analysis showed that only patient age had significant predictive value for complete tumor resection in pOC. At rOC, however, only BRCA mut status significantly correlated with optimal debulking. Patients with BRCA mut disease showed significantly prolonged overall survival (OS) by 24.3 months. Progression-free survival (PFS) was prolonged in the BRCA mut group at all stages as well, reaching statistical significance during recurrence. Conclusions Patients with BRCA mut disease showed a more aggressive course of disease with earlier onset and more extensive tumor dissemination at pOC. However, surgical outcome and OS were significantly better in patients with BRCA mut disease compared with patients with BRCA wt disease. We therefore propose to consider BRCA mut status in regard to patient selection for cytoreductive surgery, especially in rOC.
Type of Medium:
Online Resource
ISSN:
1068-9265
,
1534-4681
DOI:
10.1245/s10434-022-12459-3
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2023
detail.hit.zdb_id:
2074021-9
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