In:
FEBS Letters, Wiley, Vol. 221, No. 1 ( 1987-08-31), p. 18-22
Abstract:
Conditioned medium from human monocytes contains a partially characterized hepatocyte‐stimulating factor that simultaneously elevates the mRNA levels of the acute‐phase protein β‐fibrinogen and decreases albumin mRNA in rat hepatoma cells. We demonstrate that recombinant human B‐cell stimulatory factor 2, which is identical to interferon‐β2/26 kDa protein and interleukin‐HP1, exhibits the same activity as hepatocyte‐stimulating factor. Furthermore, a specific antibody against B‐cell stimulatory factor 2 was able to inhibit hepatocyte‐stimulating factor in conditioned medium from human monocytes. Our data show that hepatocyte‐stimulating factor and B‐cell stimulatory factor 2 are functionally and immunologically related proteins.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/0014-5793(87)80344-7
Language:
English
Publisher:
Wiley
Publication Date:
1987
detail.hit.zdb_id:
1460391-3
SSG:
12
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