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  • 1
    Online Resource
    Online Resource
    Vaccination with either mRNA or Vector-Based COVID-19 Vaccine has no Detectable Effect on Sperm Parameters
    SciRes Literature LLC ; 2022
    In:  Journal of Biomedical Research & Environmental Sciences Vol. 3, No. 9 ( 2022-10), p. 1076-1081
    Details
    In: Journal of Biomedical Research & Environmental Sciences, SciRes Literature LLC, Vol. 3, No. 9 ( 2022-10), p. 1076-1081
    Abstract: Background: With the introduction of COVID-19 vaccines in 2021, concerns arose regarding their impact on male fertility. Therefore, this study investigated the effect of mRNA- and vector-based COVID-19 vaccination on male fertility by analyzing sperm parameters in subjects with unrestricted and restricted fertility. Methods: In this prospective self before-after control study at a single University-based Infertility Center in Duesseldorf, Germany, a total of 25 male subjects were recruited, who were scheduled to receive their first vaccination against COVID-19 between January and August 2021. Semen samples were obtained before and after the first COVID-19 vaccination to perform an analysis of semen quality according to the 2010 World Health Organization guideline. Main outcome measures were ejaculate volume, sperm concentration, total sperm number, percentage of sperm motility and sperm morphology. Results: There were no significant changes in sperm parameters before and after the vaccination. Conclusion: Both, mRNA and vector-based COVID-19 vaccination had no short-term effect on sperm parameters. Therefore, an influence of COVID-19 vaccination on male fertility appears to be very unlikely.
    Type of Medium: Online Resource
    ISSN: 2766-2276
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.37871/jbres.v3i9
    DOI: 10.37871/jbres
    DOI: 10.37871/jbres1558
    Language: Unknown
    Publisher: SciRes Literature LLC
    Publication Date: 2022
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  • 2
    Online Resource
    Online Resource
    Mild COVID-19 has no detrimental effect on semen quality
    Springer Science and Business Media LLC ; 2023
    In:  Basic and Clinical Andrology Vol. 33, No. 1 ( 2023-06-15)
    Details
    In: Basic and Clinical Andrology, Springer Science and Business Media LLC, Vol. 33, No. 1 ( 2023-06-15)
    Abstract: À ce jour, l’effet de la maladie due au coronavirus 2019 (COVID-19) sur la fertilité masculine reste incertain. Les études publiées jusqu’à présent ont des résultats partiellement contradictoires, ce qui est probablement dû à la très petite taille des échantillons et l’hétérogénéité des populations. Pour mieux comprendre l’impact de la COVID-19 sur la fertilité masculine, nous avons réalisé une étude cas-témoins prospective, dans laquelle nous avons examiné l’éjaculat de 37 sujets, dont 25 sujets en phase aiguë de COVID-19 légère et 12 sujets qui ne souffraient pas de la COVID-19. La détermination des paramètres séminaux, la qPCR du coronavirus du syndrome respiratoire aigu sévère de type 2 (SRAS-CoV-2), et l’analyse de l’infectiosité ont été effectuées dans la phase aiguë de la maladie et dans la série. Résultats Les valeurs des paramètres du sperme ne différaient pas significativement entre les hommes atteints de la COVID-19 légère et ceux du groupe témoin. L’examen en série des paramètres du sperme n’a révélé aucun changement significatif entre 4, 18 et 82 jours après l’apparition des symptômes. L’ARN du SARS-CoV-2 ou les particules infectieuses n’ont été détectés dans aucun des éjaculats. Conclusion La COVID-19 de forme légère ne semble pas avoir d’effet néfaste sur les valeurs des paramètres du sperme.
    Type of Medium: Online Resource
    ISSN: 2051-4190
    URL: Article
    DOI: 10.1186/s12610-023-00190-2
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2732675-5
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  • 3
    Online Resource
    Online Resource
    One center experience with a personalized frozen-thawed embryo transfer in patients with recurrent implantation failure
    Springer Science and Business Media LLC ; 2023
    In:  Journal of Assisted Reproduction and Genetics Vol. 40, No. 7 ( 2023-07), p. 1639-1647
    Details
    In: Journal of Assisted Reproduction and Genetics, Springer Science and Business Media LLC, Vol. 40, No. 7 ( 2023-07), p. 1639-1647
    Abstract: Displaced endometrial receptivity has been discussed as a possible cause of recurrent implantation failure in patients undergoing assisted reproductive technology. The aim of this study was to document our experience with the endometrial receptivity analysis in patients with recurrent implantation failure. Methods This retrospective cohort study, conducted at the Fertility Centre of the University Hospital, Duesseldorf Germany, presents the results of the endometrial receptivity analysis in 67 patients with recurrent implantation failure and compares the clinical outcome between these 67 patients who underwent a personalized frozen-thawed embryo transfer guided by the results of the endometrial receptivity analysis and 32 patients with recurrent implantation failure who performed a standardized frozen-thawed embryo transfer. Results The data analysis revealed a displaced endometrial receptivity in 73% (49/67) of all tested patients. Out of these patients, 24% (12/49) were early receptive, 74% (36/49) were pre-receptive, and 2% (1/49) were post-receptive. Comparison of pregnancy rate, clinical pregnancy rate, and live-birth rate between personalized (49%, 39%, 27%, respectively) and standardized embryo transfer (44%, 31%, 19%, respectively) reveals no statistically significant difference. In both groups, patients had an average of four unsuccessful embryo transfers. Conclusion In this cohort of patients with recurrent implantation failure, the endometrial receptivity analysis showed a high incidence of displaced endometrial receptivity. However, a personalized embryo transfer did not increase reproductive outcome. Displaced endometrial receptivity might not be the main cause for recurrent implantation failure in this cohort.
    Type of Medium: Online Resource
    ISSN: 1058-0468 , 1573-7330
    URL: Article
    DOI: 10.1007/s10815-023-02835-7
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2016722-2
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  • 4
    Online Resource
    Online Resource
    Syndecan-1 Acts as an Important Regulator of CXCL1 Expression and Cellular Interaction of Human Endometrial Stromal and Trophoblast Cells
    Hindawi Limited ; 2017
    In:  Mediators of Inflammation Vol. 2017 ( 2017), p. 1-14
    Details
    In: Mediators of Inflammation, Hindawi Limited, Vol. 2017 ( 2017), p. 1-14
    Abstract: Successful implantation of the embryo into the human receptive endometrium is substantial for the establishment of a healthy pregnancy. This study focusses on the role of Syndecan-1 at the embryo-maternal interface, the multitasking coreceptor influencing ligand concentration, release and receptor presentation, and cellular morphology. CXC motif ligand 1, being involved in chemotaxis and angiogenesis during implantation, is of special interest as a ligand of Syndecan-1. Human endometrial stromal cells with and without Syndecan-1 knock-down were decidualized and treated with specific inhibitors to evaluate signaling pathways regulating CXC ligand 1 expression. Western blot analyses of MAPK and Wnt members were performed, followed by analysis of spheroid interactions between human endometrial cells and extravillous trophoblast cells. By mimicking embryo contact using IL-1 β , we showed less ERK and c-Jun activation by depletion of Syndecan-1 and less Frizzled 4 production as part of the canonical Wnt pathway. Additionally, more beta-catenin was phosphorylated and therefore degraded after depletion of Syndecan-1. Secretion of CXC motif ligand 1 depends on MEK-1 with respect to Syndecan-1. Regarding the interaction of endometrial and trophoblast cells, the spheroid center-to-center distances were smaller after depletion of Syndecan-1. Therefore, Syndecan-1 seems to affect signaling processes relevant to signaling and intercellular interaction at the trophoblast-decidual interface.
    Type of Medium: Online Resource
    ISSN: 0962-9351 , 1466-1861
    URL: Article
    DOI: 10.1155/2017/8379256
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2008065-7
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