In:
Science Immunology, American Association for the Advancement of Science (AAAS), Vol. 8, No. 80 ( 2023-02-24)
Abstract:
Complement proteins are innate immune defense molecules that protect the host against pathogenic microorganisms. The activities of the C3 component of complement are mostly attributed to circulating C3 primarily synthesized by hepatocytes. Sahu and Ozantürk et al . used mouse models of conditional gene deletion to investigate the contribution of local C3 protein production in the lung to protecting the pulmonary mucosal surface from cell damage caused by Pseudomonas aeruginosa infection. Mice lacking C3 only in lung epithelial cells exhibited more pronounced acute lung injury than control mice even so circulating C3 levels were maintained at near-normal levels by maintenance of liver C3 production. These findings point to lung epithelial cell-intrinsic protective functions provided by C3 as an essential contributor to first-line defense against bacterial pneumonia.—IRW
Type of Medium:
Online Resource
ISSN:
2470-9468
DOI:
10.1126/sciimmunol.abp9547
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2023
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