In:
International Journal of Cancer, Wiley, Vol. 139, No. 4 ( 2016-08-15), p. 916-927
Abstract:
What's New? New therapies for triple‐negative breast cancer (TNBC) are urgently needed. It would be ideal if such a therapy could specifically target TNBC cells. In this study, the authors engineered a fusion protein composed of an antibody fragment that binds to TNBC cells, plus a protein called MAP tau that kills these proliferating cells. This cytolytic fusion protein caused tumor regression in mice carrying human TNBC tumors. These results indicate that this novel molecule may be a promising immunotherapy for TNBC.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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