In:
European Journal of Gastroenterology & Hepatology, Ovid Technologies (Wolters Kluwer Health), Vol. 32, No. 5 ( 2020-05), p. 588-596
Kurzfassung:
The aims of this study were (a) to know the kinetics of antitumor necrosis factor (TNF) drug serum levels during the induction phase in patients with Crohn’s disease; (b) to identify variables associated with these levels; and (c) to assess the relation between these levels and short-term effectiveness in Crohn’s disease patients. Methods Patients with Crohn’s disease naïve to anti-TNF treatment were prospectively included. Remission was defined as a Crohn’s disease activity index (CDAI) score 〈 150 after 14 weeks of treatment. Blood samples were obtained at baseline and at weeks 4, 8, and 14. Adalimumab and infliximab levels were measured, receiver operating characteristic (ROC) curves were constructed, and the area under the ROC curve was calculated. Results One-hundred fifty patients with Crohn’s disease were included, 79 (53%) received infliximab and 71 (47%) had CDAI 〉 150 at study entry. At week 14, 52 out of 71 patients with CDAI 〉 150 at baseline (73%) had clinical remission. There were no differences in infliximab levels between patients with and without remission (8 vs. 9.1 μg/mL, P 〉 0.05) or with and without response (7 vs. 11 μg/mL, P 〉 0.05) at week 14. There was a trend to higher levels of adalimumab concentration in responders in comparison with nonresponders (13 vs. 6.7 μg/mL, P = 0.05) and in patients who achieved remission in comparison with nonremitters (13.5 vs. 8.4 μg/mL, P = 0.06). In the multivariate analysis, no variable was predictive of short-term remission, including infliximab and adalimumab serum levels. Conclusion Determining anti-TNF serum levels during the induction phase is not useful for predicting short-term remission in patients with Crohn’s disease.
Materialart:
Online-Ressource
ISSN:
0954-691X
DOI:
10.1097/MEG.0000000000001706
Sprache:
Englisch
Verlag:
Ovid Technologies (Wolters Kluwer Health)
Publikationsdatum:
2020
ZDB Id:
2030291-5
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