In:
Journal of the American Geriatrics Society, Wiley, Vol. 62, No. 4 ( 2014-04), p. 690-695
Abstract:
To determine whether there is greater risk of initiation of oxybutynin to treat urinary incontinence ( UI ) after initiation of medicines reported to be associated with UI . Design Prescription sequence symmetry analysis ( PSSA ). Setting Administrative claims data from the A ustralian G overnment D epartment of V eterans' A ffairs. Participants Individuals who initiated oxybutynin and a medicine reported to be associated with UI in a 12‐month period. Measurements Between J anuary 1, 2001, and D ecember 31, 2011, the distribution of incident dispensing of medicines reported to be associated with UI (prazosin, diuretics, calcium channel blockers ( CCB s), angiotensin‐converting enzyme inhibitors ( ACE Is), angiotensin receptor blockers ( ARB s), hormone replacement therapy ( HRT ), opioid analgesics, anticonvulsants, levodopa, antipsychotics, sedatives, selective serotonin reuptake inhibitors ( SSRI s), venlafaxine, anticholinesterases) was assessed before and after incident dispensing of oxybutynin (to treat UI ). Crude and adjusted sequence ratios ( ASR s) with 95% confidence intervals ( CI s) were calculated. Results Significant associations between initiation of CCB s, ACEI s, ARB s, and hypnotic‐sedatives and subsequent initiation of oxybutynin were found. ASR s ranged from 1.28 (95% CI = 1.19–1.39) for ACEI s to 1.59 (95% CI = 1.29–1.96) for verapamil. In women, there was greater risk of initiation of oxybutynin after prazosin ( ASR = 1.84, 95% CI = 1.29–2.63) and HRT ( ASR = 1.54, 95% CI = 1.42–1.67) initiation. PSSA showed no significant association with initiation of opioids, anticonvulsants, levodopa, SSRI s, venlafaxine, or anticholinesterases and subsequent initiation of oxybutynin. Conclusion This study highlights the potential for initiation of commonly used medicines to be associated with subsequent initiation of oxybutynin to treat UI . Greater awareness of the potential for medicines to contribute to UI is required.
Type of Medium:
Online Resource
ISSN:
0002-8614
,
1532-5415
DOI:
10.1111/jgs.2014.62.issue-4
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2040494-3
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