In:
Diabetes, American Diabetes Association, Vol. 54, No. 1 ( 2005-01-01), p. 100-106
Abstract:
Islet transplantation can provide metabolic stability for patients with type 1 diabetes; however, more than one donor pancreas is usually required to achieve insulin independence. To evaluate possible mechanistic defects underlying impaired graft function, we studied five subjects at 3 months and four subjects at 12 months following intraportal islet transplantation who had received comparable islet equivalents per kilogram (12,601 ± 1,732 vs. 14,384 ± 2,379, respectively). C-peptide responses, as measures of β-cell function, were significantly impaired in both transplant groups when compared with healthy control subjects (P & lt; 0.05) after intravenous glucose (0.3 g/kg), an orally consumed meal (600 kcal), and intravenous arginine (5 g), with the greatest impairment to intravenous glucose and a greater impairment seen in the 12-month compared with the 3-month transplant group. A glucose-potentiated arginine test, performed only in insulin-independent transplant subjects (n = 5), demonstrated significant impairments in the glucose-potentiation slope (P & lt; 0.05) and the maximal response to arginine (ARmax; P & lt; 0.05), a measure of β-cell secretory capacity. Because ARmax provides an estimate of the functional β-cell mass, these results suggest that a low engrafted β-cell mass may account for the functional defects observed after islet transplantation.
Type of Medium:
Online Resource
ISSN:
0012-1797
,
1939-327X
DOI:
10.2337/diabetes.54.1.100
Language:
English
Publisher:
American Diabetes Association
Publication Date:
2005
detail.hit.zdb_id:
1501252-9
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