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  • 1
    In: BMC Psychiatry, Springer Science and Business Media LLC, Vol. 22, No. 1 ( 2022-12)
    Abstract: Information on the off–label use of Long–Acting Injectable (LAI) antipsychotics in the real world is lacking. In this study, we aimed to identify the sociodemographic and clinical features of patients treated with on– vs off–label LAIs and predictors of off–label First– or Second–Generation Antipsychotic (FGA vs. SGA) LAI choice in everyday clinical practice. Method In a naturalistic national cohort of 449 patients who initiated LAI treatment in the STAR Network Depot Study, two groups were identified based on off– or on–label prescriptions. A multivariate logistic regression analysis was used to test several clinically relevant variables and identify those associated with the choice of FGA vs SGA prescription in the off–label group. Results SGA LAIs were more commonly prescribed in everyday practice, without significant differences in their on– and off–label use. Approximately 1 in 4 patients received an off–label prescription. In the off–label group, the most frequent diagnoses were bipolar disorder (67.5%) or any personality disorder (23.7%). FGA vs SGA LAI choice was significantly associated with BPRS thought disorder (OR = 1.22, CI95% 1.04 to 1.43, p  = 0.015) and hostility/suspiciousness (OR = 0.83, CI95% 0.71 to 0.97, p  = 0.017) dimensions. The likelihood of receiving an SGA LAI grew steadily with the increase of the BPRS thought disturbance score. Conversely, a preference towards prescribing an FGA was observed with higher scores at the BPRS hostility/suspiciousness subscale. Conclusion Our study is the first to identify predictors of FGA vs SGA choice in patients treated with off–label LAI antipsychotics. Demographic characteristics, i.e. age, sex, and substance/alcohol use co–morbidities did not appear to influence the choice towards FGAs or SGAs. Despite a lack of evidence, clinicians tend to favour FGA over SGA LAIs in bipolar or personality disorder patients with relevant hostility. Further research is needed to evaluate treatment adherence and clinical effectiveness of these prescriptive patterns.
    Type of Medium: Online Resource
    ISSN: 1471-244X
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2050438-X
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  • 2
    Online Resource
    Online Resource
    SAGE Publications ; 2004
    In:  The Canadian Journal of Psychiatry Vol. 49, No. 9 ( 2004-09), p. 613-620
    In: The Canadian Journal of Psychiatry, SAGE Publications, Vol. 49, No. 9 ( 2004-09), p. 613-620
    Abstract: To assess patients' opinions on the perceived benefit of treatment delivered during their stay in a residential facility. Method: We administered the Opinions on Curative Factors Questionnaire (OCFQ), which was developed from previous studies and assesses several treatment modalities and therapeutic factors, to a sample of 157 severely ill psychiatric patients admitted to a residential facility. Results: All therapeutic factors tested by the OCFQ were considered helpful or very helpful by most of those sampled. The item with the highest score was “talking to doctor,” followed by “free pass,” “medication,” “visitors,” “nonhospital setting,” “making friends with patients,” “structure of daily life,” “support from team,” and “talking to nurses.” The least-valued item was “group activities.” Conclusion: Psychiatric patients consider several treatment factors to be helpful, especially those based on individual approaches or on a less restrictive therapeutic milieu that allows interactions with the outside world. These results may be a valuable contribution to improving treatment planning in residential facilities.
    Type of Medium: Online Resource
    ISSN: 0706-7437 , 1497-0015
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2004
    detail.hit.zdb_id: 2035338-8
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