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  • International Union of Crystallography (IUCr)  (2)
  • Bao, Yuan  (2)
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  • International Union of Crystallography (IUCr)  (2)
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  • 1
    Online Resource
    Online Resource
    A novel crystal-analyzer phase retrieval algorithm and its noise property
    International Union of Crystallography (IUCr) ; 2015
    In:  Journal of Synchrotron Radiation Vol. 22, No. 3 ( 2015-05-01), p. 786-795
    Details
    In: Journal of Synchrotron Radiation, International Union of Crystallography (IUCr), Vol. 22, No. 3 ( 2015-05-01), p. 786-795
    Abstract: A description of the rocking curve in diffraction enhanced imaging (DEI) is presented in terms of the angular signal response function and a simple multi-information retrieval algorithm based on the cosine function fitting. A comprehensive analysis of noise properties of DEI is also given considering the noise transfer characteristic of the X-ray source. The validation has been performed with synchrotron radiation experimental data and Monte Carlo simulations based on the Geant4 toolkit combined with the refractive process of X-rays, which show good agreement with each other. Moreover, results indicate that the signal-to-noise ratios of the refraction and scattering images are about one order of magnitude better than that of the absorption image at the edges of low- Z samples. The noise penalty is drastically reduced with the increasing photon flux and visibility. Finally, this work demonstrates that the analytical method can build an interesting connection between DEI and GDPCI (grating-based differential phase contrast imaging) and is widely suitable for a variety of measurement noise in the angular signal response imaging prototype. The analysis significantly contributes to the understanding of noise characteristics of DEI images and may allow improvements to the signal-to-noise ratio in biomedical and material science imaging.
    Type of Medium: Online Resource
    ISSN: 1600-5775
    URL: Article
    DOI: 10.1107/S1600577515003616
    Language: Unknown
    Publisher: International Union of Crystallography (IUCr)
    Publication Date: 2015
    detail.hit.zdb_id: 2021413-3
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Three-dimensional study of poly(lactic co-glycolic acid) micro-porous microspheres using hard X-ray nano-tomography
    International Union of Crystallography (IUCr) ; 2014
    In:  Journal of Synchrotron Radiation Vol. 21, No. 5 ( 2014-09-01), p. 1175-1179
    Details
    In: Journal of Synchrotron Radiation, International Union of Crystallography (IUCr), Vol. 21, No. 5 ( 2014-09-01), p. 1175-1179
    Abstract: Poly(lactic co-glycolic acid) (PLGA) is widely used in diverse fields, especially in delivering biologically active proteins and drugs. For these applications, the knowledge of morphology and microstructure of PLGA micro-porous microspheres is of great importance since they strongly influence the drug delivering efficiency. In this study, micro-porous PLGA microspheres loaded by bovine serum albumin are investigated by using a full-field Zernike phase contrast transmission hard X-ray microscope. From three-dimensional reconstructions and segmentations, fundamental microstructural parameters such as size, shape, distribution and volume ratio among pores and proteins inside PLGA microspheres were obtained. These parameters are useful to understand the relationship between the internal microstructure and drug encapsulation, as well as the drug release efficiency of PLGA microspheres. The presented results demonstrate the capability of hard X-ray nano-tomography to characterize porous microspheres loaded with proteins and drugs, and also open a way to analyse, optimize and design new PLGA microspheres for specific applications.
    Type of Medium: Online Resource
    ISSN: 1600-5775
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.1107/S1600577514014611
    DOI: 10.1107/S1600577514014611/hf5256sup1.mpg
    DOI: 10.1107/S1600577514014611/hf5256sup2.mpg
    DOI: 10.1107/S1600577514014611/hf5256sup3.mpg
    Language: Unknown
    Publisher: International Union of Crystallography (IUCr)
    Publication Date: 2014
    detail.hit.zdb_id: 2021413-3
    Location Call Number Limitation Availability
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    Online Resource
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