In:
British Journal of Haematology, Wiley, Vol. 185, No. 3 ( 2019-05), p. 541-548
Abstract:
Neurological manifestations are reported only occasionally in patients with thalassaemia and are given much less prominence than the complications related to anaemia and iron overload. White matter changes ( WMC s) on magnetic resonance imaging ( MRI ) in patients with thalassaemia were first reported two decades ago but the significance of these lesions remains unclear. We studied the neurological and cognitive manifestations in 82 older patients with thalssaemia [25 Thalassaemia major ( TM ), 24 thalassaemia intermedia ( TI ) and 33 haemaglobin E β thalassaemia ( EBT )] and 80 controls, and found that headaches were more common in thalassaemia patients (50/82, 61%) than in controls (18/80, 22·5%: P 〈 0·001). WMC s on MRI were found in 20/82 (24·3%) patients and 2/29 (6·9%) controls had ( P = 0·078). WMC were more common among those with headaches (17/50: 34%) than in those without headache (3/32; 9·3%) ( P = 0·023). WMC s were not associated with reduction of cognition. Nevertheless, cognition was lower in the TI and EBT groups compared with those with TM ( P = 0·002). The association of headache with WMC in thalassaemia has not been reported before and warrants further study.
Type of Medium:
Online Resource
ISSN:
0007-1048
,
1365-2141
DOI:
10.1111/bjh.2019.185.issue-3
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
1475751-5
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