In:
Diabetes and Vascular Disease Research, SAGE Publications, Vol. 9, No. 1 ( 2012-01), p. 3-9
Abstract:
Background: We investigated the association between diabetes mellitus (DM) and all-cause mortality in a large cohort of consecutive patients treated with primary percutaneous coronary intervention (PPCI) in the contemporary era. Methods: We conducted a retrospective analysis of a single-centre registry of patients undergoing PPCI for ST-segment elevation myocardial infarction (STEMI) at a large regional PCI centre between 2005 and 2009. All-cause mortality in relation to patient and procedural characteristics was compared between patients with and without DM. Results: Of 2586 patients undergoing PPCI, 310 (12%) had DM. Patients with DM had a higher prevalence of multi-vessel coronary disease ( p 〈 0.001) and prior myocardial infarction ( p 〈 0.001). Patients with DM were less commonly admitted directly to the interventional centre ( p=0.002). Symptom-to-balloon ( p 〈 0.001) and door-to-balloon time ( p=0.002) were longer in patients with DM. Final infarct-related-artery TIMI-flow grade was lower in patients with DM ( p=0.031). All-cause mortality at 30 days ( p=0.0025) and 1 year ( p 〈 0.0001) was higher in patients with DM. DM was independently associated with increased mortality after multivariate adjustment for potential confounders. Conclusions: Mortality remains substantially higher in patients with DM following reperfusion for STEMI in comparison with those without diabetes, despite contemporary management with PPCI. Greater co-morbidity, delayed presentation, longer times-to-reperfusion, and less optimal reperfusion may contribute to adverse outcomes.
Type of Medium:
Online Resource
ISSN:
1479-1641
,
1752-8984
DOI:
10.1177/1479164111427752
Language:
English
Publisher:
SAGE Publications
Publication Date:
2012
detail.hit.zdb_id:
2250797-8
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