In:
Science Translational Medicine, American Association for the Advancement of Science (AAAS), Vol. 15, No. 706 ( 2023-07-26)
Abstract:
Numerous studies have relied on analyzing peripheral blood to understand how T cells mediate graft-versus-host disease (GVHD) but little is known about these responses at the tissue level. DeWolf et al . compared site-specific T cell receptor (TCR) repertoires across a range of tissues from prospectively collected autopsies from patients with or without GVHD and in GVHD murine models. They consistently found similar TCR repertoires in tissues from similar anatomic sites regardless of patient disease status and confirmed that TCRs in peripheral blood offered a narrow view of the TCR repertoire observed in tissues. They also detected tissue-resident T cells at disease sites in some patients with evidence for donor origin. This study provides insight into the T cell composition in tissues associated with GVHD and highlights the powerful insights gained from directly analyzing tissues. —Christiana Fogg
Type of Medium:
Online Resource
ISSN:
1946-6234
,
1946-6242
DOI:
10.1126/scitranslmed.abq0476
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2023
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