In:
Biomarkers in Medicine, Future Medicine Ltd, Vol. 5, No. 6 ( 2011-12), p. 827-835
Abstract:
Aim: The aim of this study was to evaluate the association between the circulating BMP-4 levels and atherosclerosis in patients with Type 2 diabetes. Material & methods: Serum BMP-4 levels were measured in 174 diabetic patients, and the degree of atherosclerosis was assessed by measuring the carotid intima-media thickness and the cardio-ankle vascular index. Results: Serum BMP-4 levels were inversely correlated with systolic blood pressure, triglycerides, free fatty acids, cardio-ankle vascular index and carotid intima-media thickness. Lower BMP-4 levels were shown to be an independent predictor of the increased cardio-ankle vascular index and carotid intima-media thickness after adjusting for conventional cardiovascular risk factors in patients with Type 2 diabetes. Conclusion: Serum BMP-4 levels are inversely associated with surrogate markers of arterial stiffness and carotid atherosclerosis in patients with Type 2 diabetes.
Type of Medium:
Online Resource
ISSN:
1752-0363
,
1752-0371
Language:
English
Publisher:
Future Medicine Ltd
Publication Date:
2011
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