In:
Scientific Reports, Springer Science and Business Media LLC, Vol. 5, No. 1 ( 2015-02-24)
Kurzfassung:
Gadolinium (Gd) is a unique and powerful element in chemistry and biomedicine which can be applied simultaneously to magnetic resonance imaging (MRI), X-ray computed tomography (CT) and neutron capture therapy for cancers. This multifunctionality can be maximized using gadolinium oxide (Gd 2 O 3 ) nanoparticles (GNPs) because of the large amount of Gd per GNP, making both diagnosis and therapy (i.e., theragnosis) for cancers possible using only GNPs. In this study, the T 1 MRI and CT dual imaging capability of GNPs is explored by synthesizing various iodine compound (IC) coated GNPs (IC-GNPs). All the IC-GNP samples showed stronger X-ray absorption and larger longitudinal water proton relaxivities (r 1 = 26–38 s −1 mM −1 and r 2 /r 1 = 1.4–1.9) than the respective commercial contrast agents. In vivo T 1 MR and CT images of mice were also acquired, supporting that the GNP is a potential dual imaging agent.
Materialart:
Online-Ressource
ISSN:
2045-2322
Sprache:
Englisch
Verlag:
Springer Science and Business Media LLC
Publikationsdatum:
2015
ZDB Id:
2615211-3
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