In:
Applied Physics Letters, AIP Publishing, Vol. 111, No. 6 ( 2017-08-07)
Abstract:
We report the quantitative assessment of spinal cord injury using the circularly polarized coherent anti-Stokes Raman scattering (CP-CARS) technique together with Stokes parameters in the Poincaré sphere. The pump and Stokes excitation beams are circularly polarized to suppress both the linear polarization-dependent artifacts and the nonresonant background of tissue CARS imaging, enabling quantitative CP-CARS image analysis. This study shows that CP-CARS imaging uncovers significantly increased phase retardance of injured spinal cord tissue as compared to normal tissue, suggesting that CP-CARS is an appealing label-free imaging tool for determining the degree of tissue phase retardance, which could serve as a unique diagnostic parameter associated with nervous tissue injury.
Type of Medium:
Online Resource
ISSN:
0003-6951
,
1077-3118
Language:
English
Publisher:
AIP Publishing
Publication Date:
2017
detail.hit.zdb_id:
211245-0
detail.hit.zdb_id:
1469436-0
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