In:
Future Virology, Future Medicine Ltd, Vol. 9, No. 10 ( 2014-10), p. 913-920
Abstract:
ABSTRACT T cells play an important role in the clearance of acute infection and control of hepatitis B virus (HBV) infection during the chronic phase. Chronic HBV is characterized by a weak and limited T-cell response. Several hypotheses, such as presence of Tregs or occurrence of T-cell exhaustion have been proposed to explain these observations. The two registered classes of anti-HBV drugs: pegylated-IFN-α (PEG-IFN-α) and nucleos(t)ide analogs (NUCs) have, next to their antiviral effect, also an immunomodulatory effect. Although NUCs have no direct immunomodulatory effects, they may indirectly positively affect the T-cell response through their viral suppressive action. In this review, effects of both PEG-IFN-α and NUC therapy will be discussed with regard to the cellular immune response against HBV.
Type of Medium:
Online Resource
ISSN:
1746-0794
,
1746-0808
Language:
English
Publisher:
Future Medicine Ltd
Publication Date:
2014
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