GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Wiley  (2)
  • Auvinen, P.  (2)
  • 1
    Online Resource
    Online Resource
    Significant disparities in allergy prevalence and microbiota between the young people in Finnish and Russian Karelia
    Wiley ; 2017
    In:  Clinical & Experimental Allergy Vol. 47, No. 5 ( 2017-05), p. 665-674
    Details
    In: Clinical & Experimental Allergy, Wiley, Vol. 47, No. 5 ( 2017-05), p. 665-674
    Abstract: Atopic allergy has been more common among schoolchildren in Finland, as compared to Russian Karelia. These adjacent regions show one of the most contrasting socio‐economical differences in the world. Objective We explored changes in allergy from school age to young adulthood from 2003 to 2010/2012 in these two areas. The skin and nasal microbiota were also compared. Methods Randomly selected children from Finnish ( n = 98) and Russian Karelia ( n = 82) were examined in 2003, when the children were 7–11 years of age, and again in 2010 (Finnish Karelia) and 2012 (Russian Karelia). We analysed self‐reported allergy symptoms and sensitization to common allergens by serum sIgE values. The skin (volar forearm) and nasal mucosa microbiota, collected in 2012 (aged 15–20 years), identified from DNA samples, were compared with multivariate methods. Results Asthma, hay fever, atopic eczema, self‐reported rhinitis, as well as atopic sensitization, were threefold to 10‐fold more common in Finland, as compared to Russian Karelia. Hay fever and peanut sensitization were almost non‐existent in Russia. These patterns remained throughout the 10‐year follow‐up. Skin microbiota, as well as bacterial and fungal communities in nasal mucosa, was contrastingly different between the populations, best characterized by the diversity and abundance of genus Acinetobacter ; more abundant and diverse in Russia. Overall, diversity was significantly higher among Russian subjects ( P skin 〈 0.0001, P nasal‐bacteria 〈 0.0001 and P nasal‐fungi 〈 0.01). Allergic diseases were not associated with microbial diversity in Finnish subjects. Conclusions and Clinical Relevance Differences in allergic phenotype, developed in early life, remain between populations. A parallel difference in the composition of skin and nasal microbiota suggests a potential underlying mechanism. Our results also suggest that high abundance and diversity of Acinetobacter might contribute to the low allergy prevalence in Russia. Implications of early‐life exposure to Acinetobacter should be further investigated.
    Type of Medium: Online Resource
    ISSN: 0954-7894 , 1365-2222
    URL: Issue
    URL: Article
    DOI: 10.1111/cea.2017.47.issue-5
    DOI: 10.1111/cea.12895
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2186232-1
    detail.hit.zdb_id: 2004469-0
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Hunt for the origin of allergy – comparing the Finnish and Russian Karelia
    Wiley ; 2015
    In:  Clinical & Experimental Allergy Vol. 45, No. 5 ( 2015-05), p. 891-901
    Details
    In: Clinical & Experimental Allergy, Wiley, Vol. 45, No. 5 ( 2015-05), p. 891-901
    Abstract: The Finnish and Russian Karelia are adjacent areas in northern Europe, socio‐economically distinct but geoclimatically similar. The Karelia Allergy Study was commenced in 1998 to characterize the allergy profiles in the two areas. Allergy prevalence had increased in Finland since the early 1960s, but the situation in Russia was unknown. The key finding was that allergic symptoms and diseases were systematically more common in Finnish children and adults than in their Russian counterparts. For example, in the early 2000s, hay fever in school children was almost non‐existent in Russian Karelia, and only 2% were sensitized to birch pollen compared with 27% in Finnish Karelia. Adult birth cohorts showed that among those born in the 1940s, the sensitization to pollens and pets was at the same low level in both countries, but among younger generation born in the late 1970s, the difference was already manifold. Seropositivity to some pathogens, microbial content in house dust and drinking water seemed to confer allergy protection in Russia. In subsequent studies, it became apparent that on the Finnish side, healthy children had a more biodiverse living environment as well as greater diversity of certain bacterial classes on their skin than atopic children. Abundance of skin commensals, especially Acinetobacter (gammaproteobacteria), associated with anti‐inflammatory gene expression in blood leucocytes. In vivo experiments with the mouse model demonstrated that intradermally applied A cinetobacter protected against atopic sensitization and lung inflammation. These observations support the notion that the epidemic of allergy and asthma results from reduced exposure to natural environments with rich microbiota, changed diet and sedentary lifestyle. Genetic studies have confirmed strong influence of lifestyle and environment. With our results from the Karelia study, a 10‐year National Allergy Programme was started in 2008 to combat the epidemic in Finland.
    Type of Medium: Online Resource
    ISSN: 0954-7894 , 1365-2222
    URL: Issue
    URL: Article
    DOI: 10.1111/cea.2015.45.issue-5
    DOI: 10.1111/cea.12527
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2186232-1
    detail.hit.zdb_id: 2004469-0
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...