In:
Experimental Dermatology, Wiley, Vol. 26, No. 4 ( 2017-04), p. 328-334
Abstract:
Psoriasis is a chronic inflammatory disease appearing as scaly erythematous cutaneous lesions, which are characterized by parakeratosis and acanthosis as well as the infiltration of immune cells, such as T helper‐1 and T helper‐17 cells. Here, we demonstrated that K d PT , a tripeptide structurally related to the C ‐terminal amino acids of alpha‐melanocyte‐stimulating hormone, which was previously shown to exhibit anti‐inflammatory effects in intestinal inflammation, ameliorated ongoing disease in the mouse model of imiquimod‐induced psoriasis‐like skin inflammation and in the small xenotransplant mouse model of psoriasis. We could show that systemic K d PT treatment significantly reduced hyperkeratosis and acanthosis in murine as well as human skin. Moreover, K d PT upregulated F oxp3 in CD 4 + T cells from mice and from peripheral blood of individuals with psoriasis and decreased the expression of type 1 inflammatory cytokines, indicating that the beneficial effect of K d PT was, at least in part, mediated by the induction of functional regulatory T cells that suppressed the activation of pathogenic CD 4 + IFN ‐γ + and CD 4 + IL ‐17 + T cells. Thus, these data might suggest K d PT as a potential novel therapeutic alternative for the treatment of psoriasis.
Type of Medium:
Online Resource
ISSN:
0906-6705
,
1600-0625
DOI:
10.1111/exd.2017.26.issue-4
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
2026228-0
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