In:
The Journal of Clinical Hypertension, Wiley, Vol. 18, No. 11 ( 2016-11), p. 1173-1179
Abstract:
This retrospective analysis aimed to examine off‐target effects on inflammatory and renal function parameters in n=78 subsequent patients treated with renal denervation ( RDN ) for resistant hypertension. Ambulatory and office blood pressure ( ABP / OBP ), serum creatinine, glomerular filtration rate ( GFR ), cystatin C, C‐reactive protein ( CRP ), interleukin‐6 ( IL ‐6), and white blood cell count ( WBC ) were assessed before, 6 and 12 months after RDN . ABP was significantly reduced by −8.2/−3.8 mm Hg ( P =.002/.021) at 1 year after RDN , while an initial OBP reduction was not sustained during follow‐up. IL ‐6 levels significantly decreased by −0.5 pg/mL ( P =.042) and by −1.7 pg/mL ( P 〈 .001) at 6 and 12 months, baseline IL ‐6 levels possibly predicting ABP response to RDN ( r =−0.295; P =.020). Concurrently, leukocyte count was reduced by −0.5 × 10 3 /μL ( P =.017) and −0.8 × 10 3 /μL ( P 〈 .001), respectively. Serum creatinine and GFR remained unchanged, but we observed a significant increase in cystatin C by 0.04 mg/L ( P =.026) and 0.14 mg/L ( P 〈 .001) at 6 and 12 months after the intervention.
Type of Medium:
Online Resource
ISSN:
1524-6175
,
1751-7176
DOI:
10.1111/jch.2016.18.issue-11
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
2058690-5
Permalink