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  • World Scientific Pub Co Pte Ltd  (5)
  • Attele, Anoja S.  (5)
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  • World Scientific Pub Co Pte Ltd  (5)
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  • 1
    Online Resource
    Online Resource
    Panax Quinquefolium L. Inhibits Thrombin-Induced Endothelin Release In Vitro
    World Scientific Pub Co Pte Ltd ; 1999
    In:  The American Journal of Chinese Medicine Vol. 27, No. 03n04 ( 1999-01), p. 331-338
    Details
    In: The American Journal of Chinese Medicine, World Scientific Pub Co Pte Ltd, Vol. 27, No. 03n04 ( 1999-01), p. 331-338
    Abstract: Endothelial cell damage is considered to be the initial step in the genesis of thrombosis and arteriosclerosis, the common precursors of cardiovascular disorders. In this study, we evaluated the protective effects of American ginseng or Panax quinquefolium L. extracts on endothelial cell injury, and investigated effects of ginseng extracts on thrombin-induced endothelin release using cultured human umbilical vein endothelial cells. We observed that when endothelial cells pretreated with 1, 10, and 100 μg/ml of Panax quinquefolium L. extracts were incubated for 4 and 24 hr with thrombin, the concentration of endothelin was significantly decreased in a concentration dependent, time related manner (at 4 hr, IC 50 = 5.1 μg/ml; at 24 hr, IC 50 = 6.2 μg/ml). We further evaluated the effects of N G -nitro-L-arginine (NLA), a nitric oxide (NO) synthetase inhibitor, on the activity of Panax quinquefolium L. extracts. Following pretreatment of cultured endothelial cells with NLA, the inhibition of thrombin-induced endothelin release by Panax quinquefolium L. was significantly reduced (P 〈 0.05). This result suggests that the pharmacological action of Panax quinquefolium L. is, at least partially, due to NO release. Our data demonstrate that American ginseng may play a therapeutic role in facilitating the hemodynamic balance of vascular endothelial cells.
    Type of Medium: Online Resource
    ISSN: 0192-415X , 1793-6853
    URL: Article
    DOI: 10.1142/S0192415X99000379
    Language: English
    Publisher: World Scientific Pub Co Pte Ltd
    Publication Date: 1999
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  • 2
    Online Resource
    Online Resource
    Analgesic Effects of Different Acupoint Stimulation Frequencies in Humans
    World Scientific Pub Co Pte Ltd ; 2003
    In:  The American Journal of Chinese Medicine Vol. 31, No. 01 ( 2003-01), p. 157-162
    Details
    In: The American Journal of Chinese Medicine, World Scientific Pub Co Pte Ltd, Vol. 31, No. 01 ( 2003-01), p. 157-162
    Abstract: Transcutaneous electrical acupoint stimulation (TEAS) provides a convenient and standardized technique for pain treatment. The cold-pressor test is a simple and reliable model in humans for the induction of tonic pain. In this controlled study, the effects of TEAS on cold pressor-induced pain were evaluated in 22 healthy human subjects. Electrical stimulation at 4 Hz and 32 Hz was applied to He-Gu (LI 4) and Nui-Guan (P 6) acupoints for 15 minutes. Pain score ratings were evaluated at four time points from 30–170 seconds during the cold-pressor test. We observed an analgesic effect at both 4 Hz and 32 Hz of stimulation, and pain score rating reductions were statistically significant compared to control (p 〈 0.01). Our data support the efficacy of TEAS analgesia. However, there was no significant difference between pain scores at 4 Hz and 32 Hz stimulation.
    Type of Medium: Online Resource
    ISSN: 0192-415X , 1793-6853
    URL: Article
    DOI: 10.1142/S0192415X03000795
    Language: English
    Publisher: World Scientific Pub Co Pte Ltd
    Publication Date: 2003
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  • 3
    Online Resource
    Online Resource
    Effects of Resibufogenin from Toad Venom on Isolated Purkinje Fibers
    World Scientific Pub Co Pte Ltd ; 2000
    In:  The American Journal of Chinese Medicine Vol. 28, No. 02 ( 2000-01), p. 187-196
    Details
    In: The American Journal of Chinese Medicine, World Scientific Pub Co Pte Ltd, Vol. 28, No. 02 ( 2000-01), p. 187-196
    Abstract: Chan su (dried toad venom) is a traditional Chinese medicine obtained from the skin venom gland of the toad. Chan su has long been used as a therapeutic agent in China and other Asian countries. Recent reports indicate that Chen su toxicity carries a high mortality rate in the United States. This study focused upon the cardiac electrophysiological and electro-toxicity effects of resibufogenin (RBG), one of the major components in Chan su. Action potentials of isolated sheep and canine heart Purkinje fibers were studied using glass microelectrode recording techniques. The results indicate that RBG significantly affected all parameters of transmembrane action potential, induced delayed after depolarization, and triggered arrhythmias in sheep and canine Purkinje fibers.
    Type of Medium: Online Resource
    ISSN: 0192-415X , 1793-6853
    URL: Article
    DOI: 10.1142/S0192415X00000234
    Language: English
    Publisher: World Scientific Pub Co Pte Ltd
    Publication Date: 2000
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  • 4
    Online Resource
    Online Resource
    Effects of Qian-Kun-Nin, a Chinese Herbal Medicine Formulation, on HIV Positive Subjects: A Pilot Study
    World Scientific Pub Co Pte Ltd ; 2000
    In:  The American Journal of Chinese Medicine Vol. 28, No. 03n04 ( 2000-01), p. 305-312
    Details
    In: The American Journal of Chinese Medicine, World Scientific Pub Co Pte Ltd, Vol. 28, No. 03n04 ( 2000-01), p. 305-312
    Abstract: Qian-Kun-Nin is a Chinese herbal formulation considered to have anti-infection, anti-tumor and immuno-enhancing properties. Data from previous investigations showed that Qian-Kun-Nin causes HIV growth inhibition and immunomodulation in vitro, suggesting that this formula has the ability to inhibit HIV and modulate impaired immune functions in humans. We conducted this pilot study to evaluate the anti-retroviral and immunological enhancing effects of this formula on HIV positive subjects. Eight subjects completed the study, receiving oral Qian-Kun-Nin capsules for 24 consecutive weeks in a single blind design. Compared to baseline level, the plasma virus load decreased significantly at the end of week 12 (p 〈 0.01) and week 24 (p 〈 0.01), respectively. Four weeks after cessation of Qian-Kun-Nin treatment, plasma virus load was still significantly lower compared to baseline (p 〈 0.01). Blood CD4 cell counts were increased significantly at the end of the 12th week compared to the baseline level (p 〈 0.01). No adverse effects were observed, and no significant side effects were recorded in any subjects. These data suggest that Qian-Kun-Nin has therapeutic potential in the treatment of HIV positive patients.
    Type of Medium: Online Resource
    ISSN: 0192-415X , 1793-6853
    URL: Article
    DOI: 10.1142/S0192415X00000362
    Language: English
    Publisher: World Scientific Pub Co Pte Ltd
    Publication Date: 2000
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  • 5
    Online Resource
    Online Resource
    Anti-HIV Activity of Medicinal Herbs: Usage and Potential Development
    World Scientific Pub Co Pte Ltd ; 2001
    In:  The American Journal of Chinese Medicine Vol. 29, No. 01 ( 2001-01), p. 69-81
    Details
    In: The American Journal of Chinese Medicine, World Scientific Pub Co Pte Ltd, Vol. 29, No. 01 ( 2001-01), p. 69-81
    Abstract: The acquired immunodeficiency syndrome (AIDS) is a result of human immunodeficiency virus (HIV) infection which subsequently leads to significant suppression of immune functions. AIDS is a significant threat to the health of mankind, and the search for effective therapies to treat AIDS is of paramount importance. Several chemical anti-HIV agents have been developed. However, besides the high cost, there are adverse effects and limitations associated with using chemotherapy for the treatment of HIV infection Thus, herbal medicines have frequently been used as an alternative medical therapy by HIV positive individuals and AIDS patients. The aim of this review is to summarize research findings for herbal medicines, which are endowed with the ability to inhibit HIV. In this article, we will emphasize a Chinese herbal medicine. Scutellaria baicalensis Georgi and its identified components (i.e. baicalein and baicalin) which have been shown to inhibit infectivity and replication of HIV. Potential development of anti-AIDS compounds using molecular modeling methods will also be discussed.
    Type of Medium: Online Resource
    ISSN: 0192-415X , 1793-6853
    URL: Article
    DOI: 10.1142/S0192415X01000083
    Language: English
    Publisher: World Scientific Pub Co Pte Ltd
    Publication Date: 2001
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