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  • 1
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    Newly diagnosed diseases and the frequency of their occurrence in patients after a new coronavirus infection. Results of an International Register "Dynamics Analysis of Comorbidities in SARS-CoV-2 Survivors (ACTIV SARS-CoV-2)" (12-month follow-up)
    Silicea - Poligraf, LLC ; 2023
    In:  Russian Journal of Cardiology Vol. 28, No. 4 ( 2023-04-07), p. 5424-
    Details
    In: Russian Journal of Cardiology, Silicea - Poligraf, LLC, Vol. 28, No. 4 ( 2023-04-07), p. 5424-
    Abstract: Aim . To analyze newly diagnosed diseases and features of the post-COVID course in patients after a coronavirus disease 2019 (COVID-19) within 12-month follow-up. Material and methods . A total of 9364 consecutively hospitalized patients were included in the ACTIV registry. Enrollment of patients began on June 29, 2020, and was completed on March 30, 2021, corresponding to the first and second waves of the pandemic. Demographic, clinical, and laboratory data, computed tomography (CT) results, information about inhospital clinical course and complications of COVID-19 during hospitalization were extracted from electronic health records using a standardized data collection form. The design included follow-up telephone interviews with a standard questionnaire at 3, 6, and 12 months to examine the course of post-COVID period. Results . According to the ACTIV registry, 18,1% of patients after COVID-19 had newly diagnosed diseases (NDDs) over the next 12 months. Hypertension (HTN), type 2 diabetes and coronary artery disease (CAD) prevailed in the NDD structure. Comparison of the age-standardized incidence of NDDs (HTN, CAD, diabetes) in the post-COVID period in the ACTIV registry with NDD incidence in 2019 according to Rosstat and the expected incidence of NDDs according to the EPOHA study revealed that HTN, diabetes, CAD in patients after COVID-19 were registered more often as follows: HTN by 7,0 and 4,4 times, diabetes by 7,3 and 8,8 times, CAD by 2,3 and 2,9 times, respectively. NDDs most often developed in patients aged 47 to 70 years. Comparison of the actual and expected number of cases of newly diagnosed HTN, CAD and diabetes depending on age showed that the actual number of cases in the population of patients in the ACTIV register is significantly higher than expected for patients aged 45-69 years and for patients with hypertension or diabetes and aged 〈 45 years. Patients with NDDs, compared with patients without NDDs, had a more severe acute COVID-19 course. Statistically significant independent predictors of NDD occurrence (HTN and/or diabetes and/or CAD) within 1 year after hospital discharge were age (direct relationship), body mass index (direct relationship) and glucose levels upon admission to hospital (direct relationship). Conclusion . Available evidence suggests that a strategy for managing COVID-19 survivors should include mandatory screening for early detection of cardiovascular disease and diabetes, which will be key to reducing the risk of further COVID-19 consequences.
    Type of Medium: Online Resource
    ISSN: 2618-7620 , 1560-4071
    URL: Issue
    URL: Article
    DOI: 10.15829/1560-4071-2023-4
    DOI: 10.15829/1560-4071-2023-5424
    Language: Unknown
    Publisher: Silicea - Poligraf, LLC
    Publication Date: 2023
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  • 2
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    Clinical features of post-COVID period. Results of an International Register "Dynamics Analysis of Comorbidities in SARS-CoV-2 Survivors (ACTIV SARS-CoV-2)" (12-month follow-up)
    Silicea - Poligraf, LLC ; 2022
    In:  Russian Journal of Cardiology Vol. 28, No. 1 ( 2022-12-19), p. 5270-
    Details
    In: Russian Journal of Cardiology, Silicea - Poligraf, LLC, Vol. 28, No. 1 ( 2022-12-19), p. 5270-
    Abstract: Aim . To investigate on post-COVID period in patients of the Eurasian region. Material and methods . A total of 9364 consecutively hospitalized patients were included in ACTIV registry. Enrollment of patients began on June 29, 2020, and was completed on March 30, 2021, corresponding to the first and second waves of the pandemic. Demographic, clinical, and laboratory data, computed tomography (CT) results, information about inhospital clinical course and complications of COVID-19 during hospitalization were extracted from electronic health records using a standardized data collection form. The design included follow-up telephone interviews with a standard questionnaire at 3, 6, and 12 months to examine the course of post-COVID period. Results . According to ACTIV register, 63% of patients after COVID-19 had new adverse symptoms or exacerbations of the existing symptoms lasting for up to 1 year. After hospital discharge, 79,8% of patients sought unscheduled medical attention in the first 3 months, 79,1% at 4-6 months, and 64,8% at 7-12 months. Readmission rate was 11,8% in the first 3 months, 10,9% at 4-6 months, and 10,1% at 7-12 months. The most common reasons for unscheduled treatment in the first 3 months were uncontrolled hypertension, decompensated type 2 diabetes, destabilization of coronary artery disease, gastrointestinal disease, AF episodes, exacerbation of asthma and chronic obstructive pulmonary disease, decompensated heart failure (HF). The 12-month mortality of COVID-19 survivors after the discharge was 3,08%. Multivariate analysis showed that independent risk factors for fatal outcome were age (direct correlation), the levels of hemoglobin (inverse correlation), oxygen saturation (inverse correlation), and aspartate aminotransferase (direct correlation), as well as class III-IV HF, prior stroke, cancer, inhospital acute kidney injury. Based on these identified risk factors, a nomogram was constructed to determine the 3-month mortality risk after discharge. Conclusion . Analysis of ACTIV register showed that end of the acute phase of COVID-19 does not imply a complete recovery. 
    Type of Medium: Online Resource
    ISSN: 2618-7620 , 1560-4071
    URL: Issue
    URL: Article
    DOI: 10.15829/1560-4071-2023-1
    DOI: 10.15829/1560-4071-2023-5270
    Language: Unknown
    Publisher: Silicea - Poligraf, LLC
    Publication Date: 2022
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  • 3
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    Lipid profile in hospitalized patients with COVID-19 depending on the outcome of its acute phase: data from the international registry "Dynamics analysis of comorbidities in SARS-CoV-2 infection survivors"
    Silicea - Poligraf, LLC ; 2022
    In:  Russian Journal of Cardiology Vol. 27, No. 9 ( 2022-06-23), p. 5042-
    Details
    In: Russian Journal of Cardiology, Silicea - Poligraf, LLC, Vol. 27, No. 9 ( 2022-06-23), p. 5042-
    Abstract: Aim . To study the lipid profile in hospitalized patients with coronavirus disease 2019 (COVID-19) depending on the outcome of its acute phase according to the AKTIV international registry. Material and methods . The AKTIV registry included men and women over 18 years of age with a diagnosis of COVID-19, who were treated in a hospital. A total of 9364 patients were included in the registry, of which 623 patients were analyzed for levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C) and triglycerides on days 1-2 of hospitalization. The level of high-density lipoprotein cholesterol (HDL-C) was calculated using the Friedewald equation. Results . We found that a decrease in LDL-C level was significantly associated with an unfavorable prognosis for hospitalized patients with COVID-19. This pattern persisted in both univariate and multivariate analyses. LDL-C levels in the final multivariate model had a significant relationship with the prognosis (an increase in the death risk by 1,7 times with a decrease per 1 mmol/l). In addition, we found that the survival of patients with an indicator level of 〈 2,45 mmol/l is significantly worse than in patients with an LDL-C level ≥2,45 mmol/l. All patients with high LDL-C ((≥4,9 mmol/l) survived, while among patients with low LDL-C ( 〈 2,45 mmol/l. All patients with high LDL-C ((≥4,9 mmol/l) survived, while among patients with low LDL-C ( 〈 1,4 mmol/l), mortality was 13,04%, which was significantly higher than in patients with LDL-C ≥1,4 mmol/l (6,32%, p=0,047). Conclusion . A decrease in LDL-C in the acute period is significantly associated with an unfavorable prognosis for hospitalized patients with COVID-19. Determination of LDL-C can be included in the examination program for patients with COVID-19. However, the predictive value of this parameter requires further study in prospective clinical studies.
    Type of Medium: Online Resource
    ISSN: 2618-7620 , 1560-4071
    URL: Issue
    URL: Article
    DOI: 10.15829/1560-4071-2022-9
    DOI: 10.15829/1560-4071-2022-5042
    Language: Unknown
    Publisher: Silicea - Poligraf, LLC
    Publication Date: 2022
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  • 4
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    Clinical features of post-COVID-19 period. Results of the international register “Dynamic analysis of comorbidities in SARS-CoV-2 survivors (AKTIV SARS-CoV-2)”. Data from 6-month follow-up
    Silicea - Poligraf, LLC ; 2021
    In:  Russian Journal of Cardiology Vol. 26, No. 10 ( 2021-11-22), p. 4708-
    Details
    In: Russian Journal of Cardiology, Silicea - Poligraf, LLC, Vol. 26, No. 10 ( 2021-11-22), p. 4708-
    Abstract: Aim. To study the clinical course specifics of coronavirus disease 2019 (COVID-19) and comorbid conditions in COVID-19 survivors 3, 6, 12 months after recovery in the Eurasian region according to the AKTIV register. Material and methods. The AKTIV register was created at the initiative of the Eurasian Association of Therapists. The AKTIV register is divided into 2 parts: AKTIV 1 and AKTIV 2. The AKTIV 1 register currently includes 6300 patients, while in AKTIV 2 — 2770. Patients diagnosed with COVID-19 receiving in- and outpatient treatment have been anonymously included on the registry. The following 7 countries participated in the register: Russian Federation, Republic of Armenia, Republic of Belarus, Republic of Kazakhstan, Kyrgyz Republic, Republic of Moldova, Republic of Uzbekistan. This closed multicenter register with two nonoverlapping branches (in- and outpatient branch) provides 6 visits: 3 in-person visits during the acute period and 3 telephone calls after 3, 6, 12 months. Subject recruitment lasted from June 29, 2020 to October 29, 2020. Register will end on October 29, 2022. A total of 9 fragmentary analyzes of the registry data are planned. This fragment of the study presents the results of the post-hospitalization period in COVID-19 survivors after 3 and 6 months. Results. According to the AKTIV register, patients after COVID-19 are characterized by long-term persistent symptoms and frequent seeking for unscheduled medical care, including rehospitalizations. The most common causes of unplanned medical care are uncontrolled hypertension (HTN) and chronic coronary artery disease (CAD) and/or decompensated type 2 diabetes (T2D). During 3- and 6-month follow-up after hospitalization, 5,6% and 6,4% of patients were diagnosed with other diseases, which were more often presented by HTN, T2D, and CAD. The mortality rate of patients in the post-hospitalization period was 1,9% in the first 3 months and 0,2% for 4-6 months. The highest mortality rate was observed in the first 3 months in the group of patients with class II-IV heart failure, as well as in patients with cardiovascular diseases and cancer. In the pattern of death causes in the post-hospitalization period, following cardiovascular causes prevailed (31,8%): acute coronary syndrome, stroke, acute heart failure. Conclusion. According to the AKTIV register, the health status of patients after COVID-19 in a serious challenge for healthcare system, which requires planning adequate health system capacity to provide care to patients with COVID-19 in both acute and post-hospitalization period.
    Type of Medium: Online Resource
    ISSN: 2618-7620 , 1560-4071
    URL: Issue
    URL: Article
    DOI: 10.15829/1560-4071-2021-10
    DOI: 10.15829/1560-4071-2021-4708
    Language: Unknown
    Publisher: Silicea - Poligraf, LLC
    Publication Date: 2021
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  • 5
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    Peculiarities of polyvascular disease and the diagnostic significance of the ankle-brachial index in patients with coronary artery disease: results from the real-world registry KAMMA (Clinical registry on patient population with polyvascular disease in the Russian Federation and Eurasian countries)
    Silicea - Poligraf, LLC ; 2024
    In:  Russian Journal of Cardiology Vol. 29, No. 4 ( 2024-03-21), p. 5837-
    Details
    In: Russian Journal of Cardiology, Silicea - Poligraf, LLC, Vol. 29, No. 4 ( 2024-03-21), p. 5837-
    Abstract: Aim . To investigate the prevalence and characteristics of polyvascular disease in the Eurasian region's population with one or more previously established locations of atherosclerotic arterial damage, and to evaluate the diagnostic importance of the ankle-brachial index (ABI) as a marker for polyvascular disease (PVD). Material and methods . A total of 1837 patients were included in the main branch of the KAMMA registry (patients with PVD), among which 91,6% had coronary artery disease (CAD) (n=1683). For further analysis, the group of patients with CAD was combined with 1222 patients included in the second branch of the registry — KAMMA-cardio, forming a patient population (n=2905), in which all patients had verified CAD. The mean age of patients was 66,0 [59,0; 72,0] years, with 60,3% being male. Peripheral arteries was assessed using ultrasound examination. Results . PVD was present in 95,6% of patients with coronary atherosclerosis: dual-region involvement was observed in 51,3% of patients, three-region involvement in 37,1%, four-region involvement in 3,4%, and five-region involvement in 2,0%. Stenoses of the common carotid artery were observed in 71% of patients, internal carotid artery — in 68%, lower limb artery — in 52%, and renal and mesenteric artery — in 8,3%. There were following diagnostic effectiveness of the ABI for detecting patients with lower limb artery stenosis was: sensitivity — 58,0%, specificity — 83,6%. The quality of antithrombotic and lipid-lowering therapy was insufficient. Conclusion . In the overwhelming majority (95,6%) of patients with CAD in the KAMMA registry, PVD was revealed, with nearly half of the patients having involvement in three or more arterial zones. In the patient population with CAD, there should be an active effort to identify patients with PVD, using at least the ABI determination and active modern antithrombotic and lipid-lowering therapy according to current clinical guidelines.
    Type of Medium: Online Resource
    ISSN: 2618-7620 , 1560-4071
    URL: Issue
    URL: Article
    DOI: 10.15829/1560-4071-2024-4
    DOI: 10.15829/1560-4071-2024-5837
    Language: Unknown
    Publisher: Silicea - Poligraf, LLC
    Publication Date: 2024
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  • 6
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    Figure 4. Possible mechanisms for the development of newly diagnosed hyperglycemia/diabetes mellitus in patients with COVID-19. Adapted from [31].
    Endocrinology Research Centre ; 2023
    In:  Problems of Endocrinology Vol. 69, No. 1 ( 2023-02-25), p. 36-49
    Details
    In: Problems of Endocrinology, Endocrinology Research Centre, Vol. 69, No. 1 ( 2023-02-25), p. 36-49
    Abstract: BACKGROUND : Numerous studies indicate a high incidence of various disorders of carbohydrate metabolism against the new coronavirus infection. These disorders aggravate the course of infection and increase mortality. Thereby, analysis of risk factors for unfavorable outcomes and assessment of the long-term consequences of COVID-19 in patients with impaired carbohydrate metabolism is of great importance. AIM : To investigate the association between carbohydrate metabolism disorders in COVID-19 patients and mortality, course of infection, long-term consequences, as well as to identify risk factors for an unfavorable disease course. MATERIALS AND METHODS : A retrospective analysis of data from the combined multicenter non-interventional real-world AKTIV and AKTIV 2 registries was performed. The sample included 9290 patients who had COVID-19 with varying severity from June 29, 2020, to November 29, 2020 (AKTIV) and from October 01, 2020, to March 30, 2021 (AKTIV 2). The patients were divided into 3 groups: Group 1 — patients with intact carbohydrate metabolism, n=6606; Group 2 — patients with newly diagnosed hyperglycemia (NDH), n=1073; Group 3 — patients with a history of type 2 diabetes mellitus (DM2), n=1611. The groups were assessed for clinical and laboratory parameters, comorbidities, mortality, carbohydrate metabolic status, and well-being during the infection and at 12 months. RESULTS : The prevalence of carbohydrate metabolism disorders (CMD) was 28,9%, with DM2 patients accounting for 17,3% and patients with newly diagnosed hyperglycemia (NDH) for 11,6%. The mortality rate of patients with hyperglycemia of any origin was 10.6%, which was significantly higher compared to patients without hyperglycemia (3,9%). The probability of lethal outcome increased 2,48-fold in the group of patients with DM2 and 2,04-fold in the group of patients with NDH. At the same time, the probability of a lethal outcome decreased 2,94-fold in patients without CMD. At 12 months, patients with CMD showed a significantly higher frequency and longer persistence of complaints. This trend was more pronounced in patients with DM2 than in those with NDH. Only 1,7% of patients from the NDH group had type 2 diabetes and were receiving oral hypoglycemic medications one year after the infection. A prognostic model was developed to determine the risk of lethal outcome. The model included such known predictors as concomitant ischemic heart disease, history of myocardial infarction or stroke, blood glucose level, and age. CONCLUSION : Carbohydrate metabolism disorders aggravate the course of COVID-19 and increase mortality. One year after infection, patients with DM2 and NDH were more likely to have symptoms typical for post-COVID syndrome, and NDH resolved in most cases after the infection.
    Type of Medium: Online Resource
    ISSN: 2308-1430 , 0375-9660
    URL: Issue
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.14341/probl.2023691
    DOI: 10.14341/probl13175
    DOI: 10.14341/probl13175-6827
    DOI: 10.14341/probl13175-6828
    DOI: 10.14341/probl13175-6829
    DOI: 10.14341/probl13175-6830
    Language: Unknown
    Publisher: Endocrinology Research Centre
    Publication Date: 2023
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  • 7
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    Impact of Kidney Damage on the Course and Prognosis of COVID-19 Infection According to the International Registry «Analysis of Chronic Non-Infectious Diseases Dynamics After Covid-19 Infection in Adult Patients»
    Synapse, LLC ; 2023
    In:  The Russian Archives of Internal Medicine Vol. 13, No. 2 ( 2023-04-05), p. 116-128
    Details
    In: The Russian Archives of Internal Medicine, Synapse, LLC, Vol. 13, No. 2 ( 2023-04-05), p. 116-128
    Abstract: Objective . To study the course of the new coronavirus infection in patients with chronic kidney disease (CKD), to identify cases of acute kidney injury (AKI) in the setting of COVID-19 infection, and to access the impact of renal function on prognosis in these categories of patients during the acute phase and after hospitalization, at 3, 6, and 12 months after recovery. Materials and methods . The ACTIV and ACTIV 2 registries included men and women older than 18 years with a diagnosis of COVID-19 based on a positive PCR test for COVID-19 and a characteristic chest X-ray or computed tomography chest scan. Results . A total of 9364 patients (4404 men, average age59 [48-69]) were included in the analysis. 716 (7.67 %) patients had CKD. 8496 (90,7 %) patients had their glomerular filtration rate (GFR) measured during hospitalization, and the values were distributed as follows: ≥90 ml/min/1.73m 2  – in 4289 (50,5 %) patients, 89-60 ml/min/1.73m 2 — in 3150 (37,1 %) patients, 59-45 ml/min/1.73m 2 — in 613 (7,22 %), 44-30 ml/min/1.73m 2 — in 253 (2,98 %), 29-15 ml/min/1.73m 2 — in 110 (1,29 %), 〈 15 ml/min/1.73m 2 — in 81 (0,95 %) patients. 11.6 % of the subjects (n=1068) developed AKI during hospitalization. This complication was reported more often than cytokine storm (in 7.46 % in 687 patients, р 〈 0,001) or sepsis (in 0.17 % in 16 patients, p=620). CKD increased the risk of death by 3.94-fold in patients with COVID-19 during hospitalization compared with patients without CKD. The mortality of patients with AKI during hospitalization was 3.94 times higher than the mortality of those without AKI. CKD also affected long-term survival after hospitalization: within 3 months of follow-up, the risk of death in patients with CKD increased 4.88-fold, within 6 months — 4.24-fold, after 12 months – 8.36-fold. Conclusion . The prevalence of CKD in COVID-19 patients is similar to that in the general population. AKI developed in 11.6 % of cases with COVID-19 infection and was observed more frequently in patients with overweight and hyperglycemia. CKD and AKI increased the risk of hospital mortality in patients with COVID-19. In the group of patients with CKD, mortality increased in the post-COVID period, 3, 6 and 12 months after. The high mortality rate of patients who had AKI during the coronavirus infection was observed only in the first 3 months of follow-up in the post-COVID period.
    Type of Medium: Online Resource
    ISSN: 2411-6564 , 2226-6704
    URL: Article
    DOI: 10.20514/2226-6704-2023-13-2-116-128
    Language: Unknown
    Publisher: Synapse, LLC
    Publication Date: 2023
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  • 8
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    Acute kidney injury in patients with chronic heart failure
    Rostov State Medical University ; 2021
    In:  South Russian Journal of Therapeutic Practice Vol. 2, No. 3 ( 2021-10-03), p. 6-17
    Details
    In: South Russian Journal of Therapeutic Practice, Rostov State Medical University, Vol. 2, No. 3 ( 2021-10-03), p. 6-17
    Abstract: The problem of chronic heart failure (CHF) and especially CHF with reduced ejection fraction is one of the most significant for modern healthcare systems. This is due to the high mortality rate, reduced quality of life, frequent hospitalizations and marked comorbidity of patients with this pathology. Involvement of the kidneys in the pathological process is one of the most common comorbid conditions in cardiovascular disease. There are a large number of pathogenetic mechanisms of mutually negative impact of heart failure and renal dysfunction, reflected in the concept of «Cardiorenal syndrome». Moreover, drug therapy of CHF can be one of the causes of kidney damage. Episodes of acute circulatory decompensation as well as a new coronavirus infection (COVID-19) are particularly threatening conditions. The aim of this review is to consolidate the international literature on the problem of acute kidney injury in patients with CHF.
    Type of Medium: Online Resource
    ISSN: 2712-8156
    URL: Issue
    URL: Article
    DOI: 10.21886/2712-8156-2021-2-3
    DOI: 10.21886/2712-8156-2021-2-3-6-17
    Language: Unknown
    Publisher: Rostov State Medical University
    Publication Date: 2021
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  • 9
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    Influence of metabolic disorders on the development of renal pathology
    Rostov State Medical University ; 2022
    In:  South Russian Journal of Therapeutic Practice Vol. 3, No. 2 ( 2022-06-18), p. 7-18
    Details
    In: South Russian Journal of Therapeutic Practice, Rostov State Medical University, Vol. 3, No. 2 ( 2022-06-18), p. 7-18
    Abstract: A large contribution to the development of kidney pathology, including the progression of chronic kidney disease, is made by risk factors associated, among other things, with impaired metabolic processes. These include disorders of carbohydrate metabolism (prediabetes, diabetes mellitus), dyslipidemia, overweight, obesity, metabolic syndrome, hyperuricemia. Timely identification of these factors and their correction can be crucial for the patient in the context of kidney damage. The review presents data on the impact of disorders of carbohydrate, lipid and purine metabolism, overweight and obesity on the formation of kidney pathology.
    Type of Medium: Online Resource
    ISSN: 2712-8156
    URL: Issue
    URL: Article
    DOI: 10.21886/2712-8156-2022-3-2
    DOI: 10.21886/2712-8156-2022-3-2-7-18
    Language: Unknown
    Publisher: Rostov State Medical University
    Publication Date: 2022
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  • 10
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    Multifocal atherosclerosis: focus on the prevention of ischemic events
    Silicea - Poligraf, LLC ; 2021
    In:  Russian Journal of Cardiology Vol. 26, No. 12 ( 2021-12-11), p. 4808-
    Details
    In: Russian Journal of Cardiology, Silicea - Poligraf, LLC, Vol. 26, No. 12 ( 2021-12-11), p. 4808-
    Abstract: In patients with atherosclerotic lesions of two or more systems or multifocal atherosclerosis (MFA), the risks of ischemic events are extremely high. MFA leads not only to cardiovascular outcomes, but also to a decrease in the patient’s quality of life, life expectancy, and in most cases to disability. The prevalence of this pathology and the importance of preventing adverse outcomes are often underestimated. This literature review examines the problem of MFA in the context of key studies on the prevalence, course of multivessel disease and the reduction of the risk of cardiovascular events in this group of patients, with an emphasis on antiplatelet and anticoagulant therapy.
    Type of Medium: Online Resource
    ISSN: 2618-7620 , 1560-4071
    URL: Issue
    URL: Article
    DOI: 10.15829/1560-4071-2021-12
    DOI: 10.15829/1560-4071-2021-4808
    Language: Unknown
    Publisher: Silicea - Poligraf, LLC
    Publication Date: 2021
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