In:
Journal of Neurology, Neurosurgery & Psychiatry, BMJ, Vol. 93, No. 6 ( 2022-06), p. A31.3-A31
Abstract:
Ipilimumab is an anti-CTLA4 antibody in evaluation for the treatment of small cell lung cancer. We report a case of rapidly progressive fatal cerebellitis occurring eight months after first dosing. Pre-treatment weakly positive anti-Yo antibodies did not change. Clinically asymptomatic anti-voltage-gated calcium channel antibodies developed after ipilimumab treatment, despite lack of expression by the tumour. The patient died three weeks into the neurological illness. Post-mortem examination revealed a T cell-mediated cerebellitis, with CD8 cytotoxicity towards Purkinje cells. This demonstrates the potential for CD8 T cells to trigger neuronal autoimmunity, offering insight into the early events in paraneoplastic neurological disease. remi.guillochon@nhs.net
Type of Medium:
Online Resource
ISSN:
0022-3050
,
1468-330X
DOI:
10.1136/jnnp-2022-ABN.98
Language:
English
Publisher:
BMJ
Publication Date:
2022
detail.hit.zdb_id:
1480429-3
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