GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • MDPI AG  (17)
  • 1
    Online Resource
    Online Resource
    An Overview of Light-Mediated Impact of Graphene Oxide on Algae: Photo-Transform, Toxicity and Mechanism
    MDPI AG ; 2022
    In:  Water Vol. 14, No. 19 ( 2022-09-23), p. 2997-
    Details
    In: Water, MDPI AG, Vol. 14, No. 19 ( 2022-09-23), p. 2997-
    Abstract: Due to the unique chemical and physical properties, graphene-based nanomaterials are increasingly being introduced into various scientific fields. They all play very important roles in different fields and are widely used. Graphene oxide (GO) is one of the most popular and representative carbon nanomaterials; scientists have great research interest in it. When carbon nanomaterials such as GO are released into the aquatic environment, their physicochemical properties will be influenced by natural light, resulting in the potential change in toxic effects on aquatic organisms. Algae, as a typical aquatic organism, is extensively regarded as a model microorganism to assess the biotoxicity of nanomaterials. In this review, we overview the light-mediated impact of GO on algae. We summarize the photo-transformation of GO under different illumination conditions and the effect of illumination on the physicochemical properties of GO. Then, we combined metabolomics, genotoxicity, and proteomics with standard toxicity assays (cell division, membrane permeability, oxidative stress, photosynthesis, cellular ultrastructure, and so on) to compare native and environmentally transformed GO induction toxicological mechanisms. By correlating lights, physicochemical properties, and biotoxicity, this review is valuable for environmental fate assessments on graphene-based nanoparticles, providing a theoretical basis and support for evaluating the potential ecological health and environmental risks of graphene-based nanoparticles in real natural water environments.
    Type of Medium: Online Resource
    ISSN: 2073-4441
    URL: Article
    DOI: 10.3390/w14192997
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2521238-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Failure Mechanism of the Yizhuxiang Collapse under the Joint Effect of Freeze–Thaw and Mining
    MDPI AG ; 2023
    In:  Applied Sciences Vol. 13, No. 6 ( 2023-03-16), p. 3801-
    Details
    In: Applied Sciences, MDPI AG, Vol. 13, No. 6 ( 2023-03-16), p. 3801-
    Abstract: At 10:05 a.m. on 4 February 2022, the perilous rock mass Yizhuxiang in Leizu Town, Yuan’an County, Hubei Province, China collapsed on a large scale. The Yizhuxiang collapse was about 35 m in length, 52 m in height, and 29 m in maximum thickness. The volume of the collapse was 5.32 × 104 m3. It threatened the transport of the national trunk road, destroyed the branch road and some cement mixing station workshops, and caused serious economic losses. The rock mass exposed in the collapse was dolomite with developed joint fractures. Under the effects of mining and unloading, fractures occurred in the rock mass; the top of the rock mass was bent and deformed towards the free face; and tension cracks were formed on the rear edge. The safety ore pillar directly below the collapsed body was compressed and deformed under the action of gravity, thus accelerating the internal deformation of the rock mass and leading to the formation of multiple dominant joints inside the rock mass. In the winter of 2021, the weather was extreme, with heavy snowfall and low temperatures. Under the effects of freeze–thaw, the strength of the rock mass declined and the tension cracks further expanded so that the rock mass experienced an accelerated deformation and finally collapsed. Causes of the collapse include mining activity beneath the collapsed mass and heightened extreme weather. The cause of the landslide disaster in this area is, however, freeze–thaw, which deserves the attention of scholars and the vigilance of the local government.
    Type of Medium: Online Resource
    ISSN: 2076-3417
    URL: Article
    DOI: 10.3390/app13063801
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2704225-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    Substituent Effects of the Nitrogen Heterocycle on Indole and Quinoline HDN Performance: A Combination of Experiments and Theoretical Study
    MDPI AG ; 2023
    In:  International Journal of Molecular Sciences Vol. 24, No. 3 ( 2023-02-03), p. 3044-
    Details
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 24, No. 3 ( 2023-02-03), p. 3044-
    Abstract: Hydrodenitrogenation (HDN) experiments and density functional theory (DFT) calculations were combined herein to study the substituent effects of the nitrogen heterocycle on the HDN behaviors of indole and quinoline. Indole (IND), 2-methyl-indole (2-M-IND), 3-methyl-indole (3-M-IND), quinoline (QL), 2-methyl-quinoline (2-M-QL) and 3-methyl-quinoline (3-M-QL) were used as the HDN reactant on the NiMo/γ-Al2O3 catalyst. Some key elementary reactions in the HDN process of these nitrogen compounds on the Ni-Mo-S active nanocluster were calculated. The notable difference between IND and QL in the HDN is that dihydro-indole (DHI) can directly convert to O-ethyl aniline via the C–N bond cleavage, whereas tetrahydro-quinoline (THQ) can only break the C–N single bond via the full hydrogenation saturation of the aromatic ring. The reason for this is that the –NH and C=C groups of DHI can be coplanar and well adsorbed on the Ni-Mo-edge simultaneously during the C–N bond cleavage. In comparison, those of THQ cannot stably simultaneously adsorb on the Ni-Mo-edge because of the non-coplanarity. Whenever the methyl group locates on the α-C or the β-C atom of indole, the hydrogenation ability of the nitrogen heterocycle will be evidently weakened because the methyl group increases the space requirement of the sp3 carbon, and the impaction of the C=C groups on the Ni-S-edge cannot provide enough space. When the methyl groups are located on the α-C of quinoline, the self-HDN behavior of 2-M-QL is similar to quinoline, whereas the competitive HDN ability of 2-M-QL in the homologs is evidently weakened because the methyl group on the α-C hinders the contact between the N atom of 2-M-QL and the exposed metal atom of the coordinatively unsaturated active sites (CUS). When the methyl group locates on the β-C of quinoline, the C–N bond cleavage of 3-methyl-quinoline becomes more difficult because the methyl group on the β-C increases the steric hindrance of the C=C group. However, the competitive HDN ability of 3-M-QL is not evidently influenced because the methyl group on the β-C does not evidently hinder the adsorption of 3-M-QL on the active sites.
    Type of Medium: Online Resource
    ISSN: 1422-0067
    URL: Article
    DOI: 10.3390/ijms24033044
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2019364-6
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    N-Acetylcysteine Enhances the Recovery of Ischemic Limb in Type-2 Diabetic Mice
    MDPI AG ; 2022
    In:  Antioxidants Vol. 11, No. 6 ( 2022-05-31), p. 1097-
    Details
    In: Antioxidants, MDPI AG, Vol. 11, No. 6 ( 2022-05-31), p. 1097-
    Abstract: Critical limb ischemia (CLI) is a severe complication of diabetes mellitus that occurs without effective therapy. Excessive reactive oxygen species (ROS) production and oxidative stress play critical roles in the development of diabetic cardiovascular complications. N-acetylcysteine (NAC) reduces ischemia-induced ROS production. The present study aimed to investigate the effect of NAC on the recovery of ischemic limb in an experimental model of type-2 diabetes. TALLYHO/JngJ diabetic and SWR/J non-diabetic mice were used for developing a CLI model. For NAC treatment, mice received NAC (1 mg/mL) in their drinking water for 24 h before initiating CLI, and continuously for the duration of the experiment. Blood flow, mechanical function, histology, expression of antioxidant enzymes including superoxide dismutase (SOD)-1, SOD-3, glutathione peroxidase (Gpx)-1, catalase, and phosphorylated insulin receptor substrate (IRS)-1, Akt, and eNOS in ischemic limb were evaluated in vivo or ex vivo. Body weight, blood glucose, plasma advanced glycation end-products (AGEs), plasma insulin, insulin resistance index, and plasma TNF-a were also evaluated during the experiment. NAC treatment effectively attenuated ROS production with preserved expressions of SOD-1, Gpx-1, catalase, phosphorylated Akt, and eNOS, and enhanced the recovery of blood flow and function of the diabetic ischemic limb. NAC treatment also significantly decreased the levels of phosphorylated IRS-1 (Ser307) expression and plasma TNF-α in diabetic mice without significant changes in blood glucose and AGEs levels. In conclusion, NAC treatment enhanced the recovery of blood flow and mechanical function in ischemic limbs in T2D mice in association with improved tissue redox/inflammatory status and insulin resistance.
    Type of Medium: Online Resource
    ISSN: 2076-3921
    URL: Article
    DOI: 10.3390/antiox11061097
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2704216-9
    SSG: 15,3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    Development and Validation of a Novel Prognostic Tool to Predict Recurrence of Paroxysmal Atrial Fibrillation after the First-Time Catheter Ablation: A Retrospective Cohort Study
    MDPI AG ; 2023
    In:  Diagnostics Vol. 13, No. 6 ( 2023-03-22), p. 1207-
    Details
    In: Diagnostics, MDPI AG, Vol. 13, No. 6 ( 2023-03-22), p. 1207-
    Abstract: There is no gold standard to tell frustrating outcomes after the catheter ablation of paroxysmal atrial fibrillation (PAF). The study aims to construct a prognostic tool. We retrospectively analyzed 315 patients with PAF who underwent first-time ablation at the Second Xiangya Hospital of Central South University. The endpoint was identified as any documented relapse of atrial tachyarrhythmia lasting longer than 30 s after the three-month blanking period. Univariate Cox regression analyzed eleven preablation parameters, followed by two supervised machine learning algorithms and stepwise regression to construct a nomogram internally validated. Five factors related to ablation failure were as follows: female sex, left atrial appendage emptying flow velocity ≤31 cm/s, estimated glomerular filtration rate 〈 65.8 mL/(min·1.73 m2), P wave duration in lead aVF ≥ 120 ms, and that in lead V1 ≥ 100 ms, which constructed a nomogram. It was correlated with the CHA2DS2-VASc score but outperformed the latter evidently in discrimination and clinical utility, not to mention its robust performances in goodness-of-fit and calibration. In addition, the nomogram-based risk stratification could effectively separate ablation outcomes. Patients at risk of relapse after PAF ablation can be recognized at baseline using the proposed five-factor nomogram.
    Type of Medium: Online Resource
    ISSN: 2075-4418
    URL: Article
    DOI: 10.3390/diagnostics13061207
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2662336-5
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    Deeper Insights into the Effect of Humic Acid on Kitchen Waste Anaerobic Digestion: Enzyme Activities, Microbial Community Dynamics, and Key Metabolic Pathways
    MDPI AG ; 2023
    In:  Fermentation Vol. 9, No. 10 ( 2023-09-29), p. 881-
    Details
    In: Fermentation, MDPI AG, Vol. 9, No. 10 ( 2023-09-29), p. 881-
    Abstract: Anaerobic digestion (AD) represents one of the most eco-friendly approaches for recovering the energy from kitchen waste (KW). This study investigated the impact of humic acid (HA) on AD of KW. Batch experiments were conducted using KW as the substrate, with varying HA dosages. The results revealed that an increase in HA dosage led to an inhibition of methanogenic efficiency by 29.51% and a delayed start-up of AD. The HA exhibited dual effects on enzyme activities during AD, inhibiting hydrolytic enzymes while stimulating acidogenic enzymes. This unique interaction ultimately resulted in a significant 12.32% increase in volatile fatty acid production. Furthermore, HA induced the generation of reactive oxygen species and had a discernible impact on the activity of the electron transfer system. A bioinformatics analysis highlighted that HA promoted the abundance of microorganisms with mediated interspecies electron transfer ability, including DMER64 and Methanosaeta, as well as the Firmicutes phylum, while significantly reducing the abundance of Methanobacterium. Moreover, the KEGG pathway analysis revealed a decrease in hydrolysis and methanogenesis-related genes and an increase in acidogenesis-related genes.
    Type of Medium: Online Resource
    ISSN: 2311-5637
    URL: Article
    DOI: 10.3390/fermentation9100881
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2813985-9
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    The Control of the Expansion or Compression of Colloidal Crystals Lattice with Salt Solution
    MDPI AG ; 2024
    In:  Nanomaterials Vol. 14, No. 4 ( 2024-02-13), p. 355-
    Details
    In: Nanomaterials, MDPI AG, Vol. 14, No. 4 ( 2024-02-13), p. 355-
    Abstract: Tuning the lattice spacing or stop bands holds great significance in the design and application of materials with colloidal crystals. Typically, particle surface modifications or the application of external physical fields are needed. In this study, we demonstrated the ability to expand or compress the lattice of colloidal crystals simply by utilizing a salt solution, without the need for any special treatments to the colloidal particles. We found that by only considering the diffusiophoresis effect we cannot explain the reversion of lattice expansion to lattice compression with the increase in the salt concentration and that the diffusioosmotic flow originating from the container wall must be taken into account. Further analysis revealed that variations in the salt concentration altered the relative amplitudes between diffusiophoresis and diffusioosmosis through changing the zeta potentials of the particles and the wall, and the competition between the particle diffusiophoresis and wall diffusioosmosis lay at the center of the underlying mechanism.
    Type of Medium: Online Resource
    ISSN: 2079-4991
    URL: Article
    DOI: 10.3390/nano14040355
    Language: English
    Publisher: MDPI AG
    Publication Date: 2024
    detail.hit.zdb_id: 2662255-5
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    Downregulation of Enhancer of Zeste Homolog 2 (EZH2) is essential for the Induction of Autophagy and Apoptosis in Colorectal Cancer Cells
    MDPI AG ; 2016
    In:  Genes Vol. 7, No. 10 ( 2016-10-03), p. 83-
    Details
    In: Genes, MDPI AG, Vol. 7, No. 10 ( 2016-10-03), p. 83-
    Type of Medium: Online Resource
    ISSN: 2073-4425
    URL: Article
    DOI: 10.3390/genes7100083
    Language: English
    Publisher: MDPI AG
    Publication Date: 2016
    detail.hit.zdb_id: 2527218-4
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    Covalently Targeted Highly Conserved Tyr318 to Improve the Drug Resistance Profiles of HIV-1 NNRTIs: A Proof-of-Concept Study
    MDPI AG ; 2023
    In:  International Journal of Molecular Sciences Vol. 24, No. 2 ( 2023-01-07), p. 1215-
    Details
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 24, No. 2 ( 2023-01-07), p. 1215-
    Abstract: This study presents proof of concept for designing a novel HIV-1 covalent inhibitor targeting the highly conserved Tyr318 in the HIV-1 non-nucleoside reverse transcriptase inhibitors binding pocket to improve the drug resistance profiles. The target inhibitor ZA-2 with a fluorosulfate warhead in the structure was found to be a potent inhibitor (EC50 = 11–246 nM) against HIV-1 IIIB and a panel of NNRTIs-resistant strains, being far superior to those of NVP and EFV. Moreover, ZA-2 was demonstrated with lower cytotoxicity (CC50 = 125 µM). In the reverse transcriptase inhibitory assay, ZA-2 exhibited an IC50 value of 0.057 µM with the ELISA method, and the MALDI-TOF MS data demonstrated the covalent binding mode of ZA-2 with the enzyme. Additionally, the molecular simulations have also demonstrated that compounds can form covalent binding to the Tyr318.
    Type of Medium: Online Resource
    ISSN: 1422-0067
    URL: Article
    DOI: 10.3390/ijms24021215
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2019364-6
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    Characterizing Stakeholders of Aging-in-Place through Social Network Analysis: A Study of Nanjing, China
    MDPI AG ; 2019
    In:  Sustainability Vol. 11, No. 23 ( 2019-11-27), p. 6722-
    Details
    In: Sustainability, MDPI AG, Vol. 11, No. 23 ( 2019-11-27), p. 6722-
    Abstract: China currently has an elderly population of 249 million with over 97% of them ending up aging in place. Although various regional pilot programs have been conducted, a sustainable aging-in-place system has not been established to effectively and efficiently provide aging services in many cities of China. The characteristics of stakeholder networks in the aging-in-place systems have not attracted great attention from researchers. This research applies social network analysis to characterize the interactions of stakeholders in aging-in-place systems to facilitate cooperation and coordination amongst them. Using Nanjing as a case study, 23 stakeholders in Nanjing’s aging-in-place system are identified, such as the Aging Affairs Committee, Aging-in-Place Service Association, and aging-in-place service centers; and then the relationship networks of these stakeholders in terms of communication, supervision, and trust are developed and analyzed. The results show that the aging-in-place system suffers from certain defects, including the loose connection of government departments, redundant information channels, low trustworthiness of certain aging-in-place service centers, poor credibility of third-party training and assessment institutions, and excess power of the industry association. To tackle these issues, a wide spectrum of actionable measures applicable to Nanjing’s conditions, as well as high-level policy implications for other cities of China, are proposed for augmenting the communication, supervision, and trust among stakeholder groups.
    Type of Medium: Online Resource
    ISSN: 2071-1050
    URL: Article
    DOI: 10.3390/su11236722
    Language: English
    Publisher: MDPI AG
    Publication Date: 2019
    detail.hit.zdb_id: 2518383-7
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...