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Common variants of the BRCA1 wild-type allele modify the risk of breast cancer in BRCA1 mutation carriers

Cox, David G. ; Simard, Jacques ; Sinnett, Daniel ; [et al.]

Oxford University Press (OUP) ; 2011

In: Human Molecular Genetics Vol. 20, No. 23 ( 2011-12-01), p. 4732-4747

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In: Human Molecular Genetics, Oxford University Press (OUP), Vol. 20, No. 23 ( 2011-12-01), p. 4732-4747

Type of Medium: Online Resource

ISSN: 1460-2083 , 0964-6906

URL: Article

DOI: 10.1093/hmg/ddr388

RVK:

XA 10000

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2011

detail.hit.zdb_id: 1474816-2

SSG: 12

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Author Correction: A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

Coignard, Juliette ; Lush, Michael ; Beesley, Jonathan ; [et al.]

Springer Science and Business Media LLC ; 2021

In: Nature Communications Vol. 12, No. 1 ( 2021-05-14)

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In: Nature Communications, Springer Science and Business Media LLC, Vol. 12, No. 1 ( 2021-05-14)

Abstract: A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-23162-4

Type of Medium: Online Resource

ISSN: 2041-1723

URL: Article

DOI: 10.1038/s41467-021-23162-4

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2021

detail.hit.zdb_id: 2553671-0

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A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

Coignard, Juliette ; Lush, Michael ; Beesley, Jonathan ; [et al.]

Springer Science and Business Media LLC ; 2021

In: Nature Communications Vol. 12, No. 1 ( 2021-02-17)

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In: Nature Communications, Springer Science and Business Media LLC, Vol. 12, No. 1 ( 2021-02-17)

Abstract: Breast cancer (BC) risk for BRCA1 and BRCA2 mutation carriers varies by genetic and familial factors. About 50 common variants have been shown to modify BC risk for mutation carriers. All but three, were identified in general population studies. Other mutation carrier-specific susceptibility variants may exist but studies of mutation carriers have so far been underpowered. We conduct a novel case-only genome-wide association study comparing genotype frequencies between 60,212 general population BC cases and 13,007 cases with BRCA1 or BRCA2 mutations. We identify robust novel associations for 2 variants with BC for BRCA1 and 3 for BRCA2 mutation carriers, P 〈 10 −8 , at 5 loci, which are not associated with risk in the general population. They include rs60882887 at 11p11.2 where MADD , SP11 and EIF1 , genes previously implicated in BC biology, are predicted as potential targets. These findings will contribute towards customising BC polygenic risk scores for BRCA1 and BRCA2 mutation carriers.

Type of Medium: Online Resource

ISSN: 2041-1723

URL: Article

DOI: 10.1038/s41467-020-20496-3

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2021

detail.hit.zdb_id: 2553671-0

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Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk

Couch, Fergus J. ; Wang, Xianshu ; McGuffog, Lesley ; [et al.]

Public Library of Science (PLoS) ; 2013

In: PLoS Genetics Vol. 9, No. 3 ( 2013-3-27), p. e1003212-

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In: PLoS Genetics, Public Library of Science (PLoS), Vol. 9, No. 3 ( 2013-3-27), p. e1003212-

Type of Medium: Online Resource

ISSN: 1553-7404

URL: Article

DOI: 10.1371/journal.pgen.1003212

DOI: 10.1371/journal.pgen.1003212.g001

DOI: 10.1371/journal.pgen.1003212.g002

DOI: 10.1371/journal.pgen.1003212.g003

DOI: 10.1371/journal.pgen.1003212.t001

DOI: 10.1371/journal.pgen.1003212.t002

DOI: 10.1371/journal.pgen.1003212.t003

DOI: 10.1371/journal.pgen.1003212.t004

DOI: 10.1371/journal.pgen.1003212.s001

DOI: 10.1371/journal.pgen.1003212.s002

DOI: 10.1371/journal.pgen.1003212.s003

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DOI: 10.1371/journal.pgen.1003212.s005

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DOI: 10.1371/journal.pgen.1003212.s007

DOI: 10.1371/journal.pgen.1003212.s008

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DOI: 10.1371/journal.pgen.1003212.s010

DOI: 10.1371/journal.pgen.1003212.s011

DOI: 10.1371/journal.pgen.1003212.s012

DOI: 10.1371/journal.pgen.1003212.s013

DOI: 10.1371/journal.pgen.1003212.s014

DOI: 10.1371/journal.pgen.1003212.s015

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DOI: 10.1371/journal.pgen.1003212.s017

DOI: 10.1371/journal.pgen.1003212.s018

DOI: 10.1371/journal.pgen.1003212.s019

DOI: 10.1371/journal.pgen.1003212.s020

DOI: 10.1371/journal.pgen.1003212.s021

DOI: 10.1371/journal.pgen.1003212.s022

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2013

detail.hit.zdb_id: 2186725-2

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No evidence that GATA3 rs570613 SNP modifies breast cancer risk

Johnatty, Sharon E. ; kConFab Investigators ; Couch, Fergus J. ; [et al.]

Springer Science and Business Media LLC ; 2009

In: Breast Cancer Research and Treatment Vol. 117, No. 2 ( 2009-9), p. 371-379

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In: Breast Cancer Research and Treatment, Springer Science and Business Media LLC, Vol. 117, No. 2 ( 2009-9), p. 371-379

Type of Medium: Online Resource

ISSN: 0167-6806 , 1573-7217

URL: Article

DOI: 10.1007/s10549-008-0257-1

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2009

detail.hit.zdb_id: 2004077-5

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Breast Cancer Risk and 6q22.33: Combined Results from Breast Cancer Association Consortium and Consortium of Investigators on Modifiers of BRCA1/2

Kirchhoff, Tomas ; Gaudet, Mia M. ; Antoniou, Antonis C. ; [et al.]

Public Library of Science (PLoS) ; 2012

In: PLoS ONE Vol. 7, No. 6 ( 2012-6-29), p. e35706-

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In: PLoS ONE, Public Library of Science (PLoS), Vol. 7, No. 6 ( 2012-6-29), p. e35706-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0035706

DOI: 10.1371/journal.pone.0035706.g001

DOI: 10.1371/journal.pone.0035706.g002

DOI: 10.1371/journal.pone.0035706.t001

DOI: 10.1371/journal.pone.0035706.t002

DOI: 10.1371/journal.pone.0035706.t003

DOI: 10.1371/journal.pone.0035706.t004

DOI: 10.1371/journal.pone.0035706.s001

DOI: 10.1371/journal.pone.0035706.s002

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2012

detail.hit.zdb_id: 2267670-3

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