In:
Gerontology, S. Karger AG, Vol. 55, No. 2 ( 2009), p. 179-185
Abstract:
〈 i 〉 Background: 〈 /i 〉 Immunoglobulin levels are elevated in the older people. However, it is unknown whether these levels are related to mortality. 〈 i 〉 Object: 〈 /i 〉 To evaluate the association between immunoglobulin levels and mortality. 〈 i 〉 Methods: 〈 /i 〉 The study population included 697 individuals (277 males and 420 females) of 1,282 eighty-year-old individuals residing in the Fukuoka prefecture, Japan. The participants were followed for 4 years after the baseline examination. 〈 i 〉 Results: 〈 /i 〉 The hyper-IgA group, defined as a serum IgA level 〉 400 mg/dl, had high mortality using Kaplan-Meier analysis (log rank, p = 0.037). Multivariate Cox regression analyses revealed a high risk of mortality (hazard rate = 1.233, 95% confidence interval 1.109–1.491, p = 0.031) after adjusting for covariates. The high risk of mortality in the hyper-IgA group was significant in males, but not in females. Moreover, Kaplan-Meier analysis revealed that IgA was related to cancer mortality in males (log rank, p = 0.031), but not to pneumonia or cardiovascular disease. IgM and IgG levels were not related to high risk of mortality. 〈 i 〉 Conclusion: 〈 /i 〉 Serum IgA levels appear to be a predictor of mortality, especially cancer mortality in males.
Type of Medium:
Online Resource
ISSN:
0304-324X
,
1423-0003
Language:
English
Publisher:
S. Karger AG
Publication Date:
2009
detail.hit.zdb_id:
1482689-6
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