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  • Angus, P. W.  (2)
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  • 1
    Online Resource
    Online Resource
    Patterns of Coagulopathy during Liver Transplantation: Experience with the First 75 Cases using Thrombelastography
    SAGE Publications ; 1994
    In:  Anaesthesia and Intensive Care Vol. 22, No. 6 ( 1994-12), p. 659-665
    Details
    In: Anaesthesia and Intensive Care, SAGE Publications, Vol. 22, No. 6 ( 1994-12), p. 659-665
    Abstract: Using both conventional laboratory clotting profile and thrombelastography, coagulation status was monitored intraoperatively during liver transplantation in the first 75 cases performed at the Austin Hospital between June 1988 and October 1992. Superimposed on a baseline coagulopathy due to liver disease is a specific pattern of coagulation disturbance which occurs during a liver transplant. Fibrinolysis occurs in the anhepatic stage, worsens with early reperfusion and then spontaneously resolves. In addition reperfusion is associated with a transient clotting defect. If blood loss is excessive, coagulopathy due to massive transfusion may compound the situation. Thrombelastography is a measurement technique allowing rapid on-site assessment of functional clotting status’. It is particularly useful in liver transplant surgery. In combination with clinical bleeding assessment it facilitates selective use of component therapy (fresh frozen plasma, platelets and cryoprecipitate) and specific drug treatment only when it is appropriate. It also acts as a liver function test, being especially useful in assessing the graft after reperfusion.
    Type of Medium: Online Resource
    ISSN: 0310-057X , 1448-0271
    URL: Article
    DOI: 10.1177/0310057X9402200603
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1994
    detail.hit.zdb_id: 2053705-0
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Blood Loss and Transfusion Requirements in Liver Transplantation: Experience with the First 75 Cases
    SAGE Publications ; 1994
    In:  Anaesthesia and Intensive Care Vol. 22, No. 6 ( 1994-12), p. 666-671
    Details
    In: Anaesthesia and Intensive Care, SAGE Publications, Vol. 22, No. 6 ( 1994-12), p. 666-671
    Abstract: The blood loss data and transfusion requirements including blood bank, salvaged washed red cells, fresh frozen plasma and cryoprecipitate were analysed for the first 75 cases of liver transplantation performed at the Austin Hospital between June 1988 and October 1992. The mean blood loss was 8.8 litres (standard deviation 14.1) with a median value of 4.0 litres. Blood product use expressed as mean number of units (SD) was bank red blood cells 7.1 (12.7), washed red blood cells 3.9 (5.9), fresh frozen plasma 7.1 (9.1), platelets 5.1 (7.4), and cryoprecipitate 1.7 (5.1). These results demonstrate that liver transplantation can be performed without imposing excessive demands on blood transfusion services. Management should include surgical techniques to minimize bleeding and use of autologous transfusion. Use of component therapy (FFP, platelets and cryoprecipitate) should not be empirical. It should be selective on the basis of clinical bleeding assessment and guided by results of the laboratory coagulation profile and changes in thrombelastographic (TEG) parameters.
    Type of Medium: Online Resource
    ISSN: 0310-057X , 1448-0271
    URL: Article
    DOI: 10.1177/0310057X9402200604
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1994
    detail.hit.zdb_id: 2053705-0
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
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