GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Springer Science and Business Media LLC  (5)
  • Andreou, Christina  (5)
  • 1
    Online Resource
    Online Resource
    Pattern of predictive features of continued cannabis use in patients with recent-onset psychosis and clinical high-risk for psychosis
    Springer Science and Business Media LLC ; 2022
    In:  Schizophrenia Vol. 8, No. 1 ( 2022-03-09)
    Details
    In: Schizophrenia, Springer Science and Business Media LLC, Vol. 8, No. 1 ( 2022-03-09)
    Abstract: Continued cannabis use (CCu) is an important predictor for poor long-term outcomes in psychosis and clinically high-risk patients, but no generalizable model has hitherto been tested for its ability to predict CCu in these vulnerable patient groups. In the current study, we investigated how structured clinical and cognitive assessments and structural magnetic resonance imaging (sMRI) contributed to the prediction of CCu in a group of 109 patients with recent-onset psychosis (ROP). We tested the generalizability of our predictors in 73 patients at clinical high-risk for psychosis (CHR). Here, CCu was defined as any cannabis consumption between baseline and 9-month follow-up, as assessed in structured interviews. All patients reported lifetime cannabis use at baseline. Data from clinical assessment alone correctly classified 73% ( p   〈  0.001) of ROP and 59 % of CHR patients. The classifications of CCu based on sMRI and cognition were non-significant (ps  〉  0.093), and their addition to the interview-based predictor via stacking did not improve prediction significantly, either in the ROP or CHR groups (ps  〉  0.065). Lower functioning, specific substance use patterns, urbanicity and a lack of other coping strategies contributed reliably to the prediction of CCu and might thus represent important factors for guiding preventative efforts. Our results suggest that it may be possible to identify by clinical measures those psychosis-spectrum patients at high risk for CCu, potentially allowing to improve clinical care through targeted interventions. However, our model needs further testing in larger samples including more diverse clinical populations before being transferred into clinical practice.
    Type of Medium: Online Resource
    ISSN: 2754-6993
    URL: Article
    DOI: 10.1038/s41537-022-00218-y
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 3133210-9
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Association between age of cannabis initiation and gray matter covariance networks in recent onset psychosis
    Springer Science and Business Media LLC ; 2021
    In:  Neuropsychopharmacology Vol. 46, No. 8 ( 2021-07), p. 1484-1493
    Details
    In: Neuropsychopharmacology, Springer Science and Business Media LLC, Vol. 46, No. 8 ( 2021-07), p. 1484-1493
    Abstract: Cannabis use during adolescence is associated with an increased risk of developing psychosis. According to a current hypothesis, this results from detrimental effects of early cannabis use on brain maturation during this vulnerable period. However, studies investigating the interaction between early cannabis use and brain structural alterations hitherto reported inconclusive findings. We investigated effects of age of cannabis initiation on psychosis using data from the multicentric Personalized Prognostic Tools for Early Psychosis Management (PRONIA) and the Cannabis Induced Psychosis (CIP) studies, yielding a total sample of 102 clinically-relevant cannabis users with recent onset psychosis. GM covariance underlies shared maturational processes. Therefore, we performed source-based morphometry analysis with spatial constraints on structural brain networks showing significant alterations in schizophrenia in a previous multisite study, thus testing associations of these networks with the age of cannabis initiation and with confounding factors. Earlier cannabis initiation was associated with more severe positive symptoms in our cohort. Greater gray matter volume (GMV) in the previously identified cerebellar schizophrenia-related network had a significant association with early cannabis use, independent of several possibly confounding factors. Moreover, GMV in the cerebellar network was associated with lower volume in another network previously associated with schizophrenia, comprising the insula, superior temporal, and inferior frontal gyrus. These findings are in line with previous investigations in healthy cannabis users, and suggest that early initiation of cannabis perturbs the developmental trajectory of certain structural brain networks in a manner imparting risk for psychosis later in life.
    Type of Medium: Online Resource
    ISSN: 0893-133X , 1740-634X
    URL: Article
    DOI: 10.1038/s41386-021-00977-9
    RVK:
    WA 15000
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2008300-2
    SSG: 15,3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    The impact of visual dysfunctions in recent-onset psychosis and clinical high-risk state for psychosis
    Springer Science and Business Media LLC ; 2022
    In:  Neuropsychopharmacology Vol. 47, No. 12 ( 2022-11), p. 2051-2060
    Details
    In: Neuropsychopharmacology, Springer Science and Business Media LLC, Vol. 47, No. 12 ( 2022-11), p. 2051-2060
    Abstract: Subtle subjective visual dysfunctions (VisDys) are reported by about 50% of patients with schizophrenia and are suggested to predict psychosis states. Deeper insight into VisDys, particularly in early psychosis states, could foster the understanding of basic disease mechanisms mediating susceptibility to psychosis, and thereby inform preventive interventions. We systematically investigated the relationship between VisDys and core clinical measures across three early phase psychiatric conditions. Second, we used a novel multivariate pattern analysis approach to predict VisDys by resting-state functional connectivity within relevant brain systems. VisDys assessed with the Schizophrenia Proneness Instrument (SPI-A), clinical measures, and resting-state fMRI data were examined in recent-onset psychosis (ROP, n  = 147), clinical high-risk states of psychosis (CHR, n  = 143), recent-onset depression (ROD, n  = 151), and healthy controls (HC, n  = 280). Our multivariate pattern analysis approach used pairwise functional connectivity within occipital (ON) and frontoparietal (FPN) networks implicated in visual information processing to predict VisDys. VisDys were reported more often in ROP (50.34%), and CHR (55.94%) than in ROD (16.56%), and HC (4.28%). Higher severity of VisDys was associated with less functional remission in both CHR and ROP, and, in CHR specifically, lower quality of life (Qol), higher depressiveness, and more severe impairment of visuospatial constructability. ON functional connectivity predicted presence of VisDys in ROP (balanced accuracy 60.17%, p  = 0.0001) and CHR (67.38%, p  = 0.029), while in the combined ROP + CHR sample VisDys were predicted by FPN (61.11%, p  = 0.006). These large-sample study findings suggest that VisDys are clinically highly relevant not only in ROP but especially in CHR, being closely related to aspects of functional outcome, depressiveness, and Qol. Findings from multivariate pattern analysis support a model of functional integrity within ON and FPN driving the VisDys phenomenon and being implicated in core disease mechanisms of early psychosis states.
    Type of Medium: Online Resource
    ISSN: 0893-133X , 1740-634X
    URL: Article
    DOI: 10.1038/s41386-022-01385-3
    RVK:
    WA 15000
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2008300-2
    SSG: 15,3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    Cognitive subtypes in recent onset psychosis: distinct neurobiological fingerprints?
    Springer Science and Business Media LLC ; 2021
    In:  Neuropsychopharmacology Vol. 46, No. 8 ( 2021-07), p. 1475-1483
    Details
    In: Neuropsychopharmacology, Springer Science and Business Media LLC, Vol. 46, No. 8 ( 2021-07), p. 1475-1483
    Abstract: In schizophrenia, neurocognitive subtypes can be distinguished based on cognitive performance and they are associated with neuroanatomical alterations. We investigated the existence of cognitive subtypes in shortly medicated recent onset psychosis patients, their underlying gray matter volume patterns and clinical characteristics. We used a K-means algorithm to cluster 108 psychosis patients from the multi-site EU PRONIA (Prognostic tools for early psychosis management) study based on cognitive performance and validated the solution independently ( N  = 53). Cognitive subgroups and healthy controls (HC; n  = 195) were classified based on gray matter volume (GMV) using Support Vector Machine classification. A cognitively spared ( N  = 67) and impaired ( N  = 41) subgroup were revealed and partially independently validated ( N spared  = 40, N impaired  = 13). Impaired patients showed significantly increased negative symptomatology ( p fdr  = 0.003), reduced cognitive performance ( p fdr   〈  0.001) and general functioning ( p fdr   〈  0.035) in comparison to spared patients. Neurocognitive deficits of the impaired subgroup persist in both discovery and validation sample across several domains, including verbal memory and processing speed. A GMV pattern (balanced accuracy = 60.1%, p  = 0.01) separating impaired patients from HC revealed increases and decreases across several fronto-temporal-parietal brain areas, including basal ganglia and cerebellum. Cognitive and functional disturbances alongside brain morphological changes in the impaired subgroup are consistent with a neurodevelopmental origin of psychosis. Our findings emphasize the relevance of tailored intervention early in the course of psychosis for patients suffering from the likely stronger neurodevelopmental character of the disease.
    Type of Medium: Online Resource
    ISSN: 0893-133X , 1740-634X
    URL: Article
    DOI: 10.1038/s41386-021-00963-1
    RVK:
    WA 15000
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2008300-2
    SSG: 15,3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    Transdiagnostic subgroups of cognitive impairment in early affective and psychotic illness
    Springer Science and Business Media LLC ; 2023
    In:  Neuropsychopharmacology
    Details
    In: Neuropsychopharmacology, Springer Science and Business Media LLC
    Abstract: Cognitively impaired and spared patient subgroups were identified in psychosis and depression, and in clinical high-risk for psychosis (CHR). Studies suggest differences in underlying brain structural and functional characteristics. It is unclear whether cognitive subgroups are transdiagnostic phenomena in early stages of psychotic and affective disorder which can be validated on the neural level. Patients with recent-onset psychosis (ROP; N  = 140; female = 54), recent-onset depression (ROD; N  = 130; female = 73), CHR ( N  = 128; female = 61) and healthy controls (HC; N  = 270; female = 165) were recruited through the multi-site study PRONIA. The transdiagnostic sample and individual study groups were clustered into subgroups based on their performance in eight cognitive domains and characterized by gray matter volume (sMRI) and resting-state functional connectivity (rsFC) using support vector machine (SVM) classification. We identified an impaired subgroup ( N ROP  = 79, N ROD  = 30, N CHR  = 37) showing cognitive impairment in executive functioning, working memory, processing speed and verbal learning (all p   〈  0.001). A spared subgroup ( N ROP  = 61, N ROD  = 100, N CHR  = 91) performed comparable to HC. Single-disease subgroups indicated that cognitive impairment is stronger pronounced in impaired ROP compared to impaired ROD and CHR. Subgroups in ROP and ROD showed specific symptom- and functioning-patterns. rsFC showed superior accuracy compared to sMRI in differentiating transdiagnostic subgroups from HC (BAC impaired  = 58.5%; BAC spared  = 61.7%, both: p   〈  0.01). Cognitive findings were validated in the PRONIA replication sample ( N  = 409). Individual cognitive subgroups in ROP, ROD and CHR are more informative than transdiagnostic subgroups as they map onto individual cognitive impairment and specific functioning- and symptom-patterns which show limited overlap in sMRI and rsFC. Clinical trial registry name German Clinical Trials Register (DRKS). Clinical trial registry URL: https://www.drks.de/drks_web/ . Clinical trial registry number: DRKS00005042.
    Type of Medium: Online Resource
    ISSN: 0893-133X , 1740-634X
    URL: Article
    DOI: 10.1038/s41386-023-01729-7
    RVK:
    WA 15000
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2008300-2
    SSG: 15,3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...